Tumors skin cancers

Exposure to UV radiation from sunlight is the major cause of human skin cancer. Skin tumors from patients with Xeroderma pigmentosum, a DNA-repair deficiency associated with increased sensitivity to UV, show a particularly high frequency of these CC to TT transitions (Dumaz et al., 1993). Mutations at dipyrimidines have been observed in the normal skin of sun-exposed skin cancer patients (Jonason et al., 1996 Nakazawa et al., 1994 Ren et al., 1996a). The localization of mutations in skin shows striking differences with other types of cancers, with hotspots at codons 177-179 and... 

WEI H, TYE L, BRESMiK E and BiRT D F (1990) Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornilthine decarboxylase and skin tumor promotion in mice . Cancer Res, 50, 499-502. 

Kripke, M. L., Antigenicity of murine skin tumors induced by UV light, J. Natl. Cancer Inst. 53, 1333-1336, 1974. 

He shou wu, a herhal formulation has been used for the treatment of skin tumors. For topical use, the powder is mixed with sesame oil and applied. He shou wu has been used for centuries to help maintain the youthful color of one s hair and also to help diminish hair loss. Holy basil contains ursolic acid (Fig. 7) — one of the cosmetic industry s latest favorites because not only does it quickly heal the skin, it also improves elasticity and removes wrinkles. It also shows benefits for preventing skin cancer. A poultice made from the herh is used topically for its antifungal and antibacterial actions. ... 

CN073 Lo, H. H., M. F. Locniskar, D. Bechtel, CN083 and S. M. Fischer. Effects of type and amount of dietary fat on mouse skin tumor promotion. Nutr Cancer 1994 ... 

Bhide. Weak carcinogenic effect of masheri, a pyrolysed tobacco product, in mouse skin tumor models. J Cancer Res Clin Oncol 1989 115(2) 166-169. 

ZO024 Park, K. K., K. S. Chum, ]. M. Lee, S. S. Lee, and Y. ]. Surh. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 1998 129(2) 139-144. 

Kotin, P., H. L. Falk, and M. Thomas, "Production of Skin Tumors in Mice with Oxidation Products of Aliphatic Hydrocarbons, Cancer, 9, 905-909 (1956). 

Albert, R.E., Phillips, M.E., Bennett P., Burns, F., and Heimbach. R. (1969). The morphology and growth characteristics of radiation-induced epithelial skin tumors in the rat, Cancer Res. 29,658. 

O Connell, J.F., Klein-Szanto, A.J.P, DiGiovanni. D.M.. Fries, J.W. Slaga, T.J. (1986) Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res., 46, 2863-2865... 

Polysaccharides and generally carbohydrates represent the main carbon sink in the plant cell. Polysaccharides commonly serve nutritional (e.g., starch) and structural (e.g., cellulose) functions in plants. Some polysaccharides are cytotoxic against certain types of cancer, such as mouse skin cancer, or tumor lines in vitro (e.g., mouse Sarcoma-180). However, most polysaccharides exert their action through stimulation of the immune system (cancer immunotherapy). Plants containing polysaccharides with anticancer properties include the following ... 

OH)2D3 inhibited proliferation and induced differentiation and apoptosis in human colon, breast, prostate and gynecological cancers as well as several forms of hematopoietic cancer (Studzinski and Moore, 1995 van Leeuwen and Pols, 1997). Experimental animal studies show that 1, 25(OH)2D3 inhibited chemically-induced breast, colon, and skin tumors. The growth of colon, breast and prostate cancer cells, as well as melanoma and retinoblastoma cells implanted into rodents was retarded by treatment with 1, 25(OH)2D3 (Studzinski and Moore, 1995 van den Bemd et al, 2000). 

Bachelor MA, Bowden GT. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Sem Cancer Biol 2004 14 131-8. 

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