Colorectal cancer chronomodulation

Levi, F., Zidani, R., Vannetzel, J.M., Per-point, B., Focan, C., Faggiuolo, R., Chollet, P., Garufi, C., Itzhaki, M., Dogliotti L. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases a randomized multi-institutional trial. J. Natl Cancer Inst. 1994, 86 1608-1617. 

It has been suggested that chronomodulated delivery of oxaliplatin might reduce the incidence of platinum-induced neurotoxicity (118,119). In a randomized, multicenter trial in patients with previously untreated metastases from colorectal cancer, 93 patients were assigned chronotherapy and 93 were assigned constant-rate infusion (120). Chronotherapy reduced the rate of severe mucositis... 

Giacchetti S, Perpoint B, Zidani R, et al (2000) Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18 136-147... 

Levi F, Zidani R, Brienza S, Dogliotti L, Perpoint B, Rotarski M, Letourneau Y, Llory JF, Chollet P, Le Rol A, Focan C. A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxali-platrn, 5-fluorouracil, and leucovorin as initial treatment of patients with metastatic colorectal carcinoma. International Organization for Cancer Chronotherapy. Cancer 1999 85(12) 2532-40. 

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