Syrian hamster embryo cell transformation assay

Farmer P Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSl/HESl research programme on alternative cancer models results of Syrian hamster embryo cell transformation assay. International Life Sciences Institute/Health and Environmental Science Institute. Toxicol Pathol 2002 30 536-8. [Pg.142]

Kerckaert, G.A., LeBoeuf, R.A. Isfort, R.J. (1998) Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds. Toxicol. Sci., 41, 189-197... [Pg.311]

LeBoeuf RA, Kerchaert GA, Aardema MJ, et al. 1996. The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. Mutat Res 356 85-127. [Pg.437]

Barrett, J. C. Lamb, P. W. (1985) Tests with the Syrian hamster embryo cell transformation assay. Prog. Mutat. Res., 5, 623-628... [Pg.93]

Syrian hamster embryo cells Transformation assay - DiPaolo and Casto 1979... [Pg.147]

Syrian hamster embryo (cell transformation assay vapor exposure)... [Pg.42]

Syrian hamster embryo cells (clonal assay) Cell transformation No data — Amacher and Zelljadt 1983... [Pg.163]

TCS, Cell transformation, Syrian hamster embryo cells, elonal assay + NT 0.01 Barrett Lamb (1985)... [Pg.86]

Phenyl glycidyl ether induced mutations in bacteria and transformation in mammalian cells in vitro (in a Syrian hamster embryo cell clonal assay and in an assay for the enhancement of viral transformation), but did not induce chromosomal aberrations in animal cells in vitro or either micronuclei or chromosomal aberrations in vivo. It did not induce dominant lethal effects in rats (IARC, 1989). [Pg.1527]

Aniline transformed the Balb/3T3 mouse cell line at doses of 0.8 to 100 /dose-response effect), but not the Syrian hamster embryo cells (Dunkel et al. 1981). Results were negative in DNA damage assays in Escherichia coli (Mamber et al. 1983) and Bacillus subtilis (McCarroll et al. 1981). [Pg.50]

Amitrole was not genotoxic in bacterial assays and cultured mammalian cells or in rodents exposed in vivo it did induce transformation of Syrian hamster embryo cells in vitro)... [Pg.44]

Cell transformation, C3H10T14 mouse eells Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Ornithine deearboxylase superinduetion, Syrian hamster embryo eells ... [Pg.108]

RLV/Fischer rat assay without the addition of an exogenous metabolic activation system. In a single study, mouse JB6 epidermal cells were transformed by di(2-ethyl-hexyl) phthalate without activation and in one of two studies a weak response was reported in the CSHIOT A cell transformation assay with di(2-ethylhexyl) phthalate in either the absence or presence of exogenous metabolic activation. BALB/c-3T3 cells were not transformed by di(2-ethylhexyl) phthalate with or without metabolic activation. Di(2-ethylhexyl) phthalate inhibited gap-junctional intercellular communication in Chinese hamster V79 cells in six of seven studies, but not in one study of liver cells of cynomolgus monkeys in vivo. Di(2-ethylhexyl) phthalate treatment of Syrian hamster embryo cells in a two-stage exposure with 12-O-tetradecanoylphorbol 13-acetate resulted in superinduction of ornithine decarboxylase, an early event in morphological transformation no effect was seen after a one-stage treatment with di(2-ethylhexyl) phthalate alone. [Pg.115]

Ethylbenzene was non-mutagenic in bacteria, yeast and insects. In mammalian cells, it was inactive in inducing sister chromatid exchanges in Chinese hamster embryo cells but very weakly positive in cultured human l5miphocytes. It did not induce micronuclei in vivo, although it was positive in Syrian hamster embryo cells in vitro. It also caused cell transformation in these cells. Ethylbenzene induced mutations in the mouse lymphoma assay, but only at the highest non-lethal concentration tested. [Pg.257]

Gibson, D.R, Brauninger, R., Shaffi, H.S., Kerckaert, GA., LeBoeuf, R.A., Isfort, R.J. Aardema, M.J. (1997) Induction of micronuclei in Syrian hamster embryo cells comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals. Mutat. Res., 392, 61-70... [Pg.261]

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