Syrian Hamster Embryo transformation assay

Di(2-ethylhexyl) phthalate induced cell transformation in the Syrian hamster embryo clonal assay, the virally enhanced SA7/Syrian hamster embryo assay and... [Pg.114]

In one study of cell transformation in the Syrian hamster embryo clonal assay, diethanolamine had no effect after an eight-day treatment. A much larger study revealed induction of cell transformation at a similar dose after a seven-day treatment and at a much higher dose after a 24-h treatment with diethanolamine. [Pg.372]

TCS, Cell transformation, Syrian hamster embryo, elonal assay + NT 10 Barrett Lamb (1985)... [Pg.391]

Syrian hamster embryo cells (clonal assay) Cell transformation No data — Amacher and Zelljadt 1983... [Pg.163]

Sanner T, Rivedal E. 1985. Tests with the Syrian hamster embryo (SHE) cell transformation assay. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 665-671. Sato M, Ishizu S, Momotuni H. 1975. [Determination of acrylonitrile, cyanide and thiocyanate in blood and urine.] Jap J Ind Health 17 99-105. (Japanese). [Pg.118]

Aniline transformed the Balb/3T3 mouse cell line at doses of 0.8 to 100 /dose-response effect), but not the Syrian hamster embryo cells (Dunkel et al. 1981). Results were negative in DNA damage assays in Escherichia coli (Mamber et al. 1983) and Bacillus subtilis (McCarroll et al. 1981). [Pg.50]

Engelhardt, G., Schwind, K.-R., and Mulller, B., The testing of chemicals in the Syrian hamster embryo (SHE) cell transformation assay for assessment of carcinogenic potential, Toxicology In Vitro, 8, 213, 2004. [Pg.313]

Custer L, Gibson DP, Aardema MJ, Le Boeuf RA. A refined protocol for conducting the low pH 6.7 Syrian hamster embryo (SHE) cell transformation assay. Mutat Res 2000 455 129-39. [Pg.142]

Farmer P Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSl/HESl research programme on alternative cancer models results of Syrian hamster embryo cell transformation assay. International Life Sciences Institute/Health and Environmental Science Institute. Toxicol Pathol 2002 30 536-8. [Pg.142]

Amitrole was not genotoxic in bacterial assays and cultured mammalian cells or in rodents exposed in vivo it did induce transformation of Syrian hamster embryo cells in vitro)... [Pg.44]

Cell transformation, C3H10T14 mouse eells Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Cell transformation, Syrian hamster embryo eells, elonal assay Ornithine deearboxylase superinduetion, Syrian hamster embryo eells ... [Pg.108]

RLV/Fischer rat assay without the addition of an exogenous metabolic activation system. In a single study, mouse JB6 epidermal cells were transformed by di(2-ethyl-hexyl) phthalate without activation and in one of two studies a weak response was reported in the CSHIOT A cell transformation assay with di(2-ethylhexyl) phthalate in either the absence or presence of exogenous metabolic activation. BALB/c-3T3 cells were not transformed by di(2-ethylhexyl) phthalate with or without metabolic activation. Di(2-ethylhexyl) phthalate inhibited gap-junctional intercellular communication in Chinese hamster V79 cells in six of seven studies, but not in one study of liver cells of cynomolgus monkeys in vivo. Di(2-ethylhexyl) phthalate treatment of Syrian hamster embryo cells in a two-stage exposure with 12-O-tetradecanoylphorbol 13-acetate resulted in superinduction of ornithine decarboxylase, an early event in morphological transformation no effect was seen after a one-stage treatment with di(2-ethylhexyl) phthalate alone. [Pg.115]

Sanchez, J.H., Abemethy, D.J. Boreiko, C.J. (1987) Lack of di-(2-ethylhexyl) phthalate activity in the C3H/10T1/2 cell transformation system. Toxicol. In Vitro, 1, 49-53 Sarmer, T. Rivedal, E. (1985) Tests with the Syrian hamster embryo (SHE) cell transformation assay. Prog. Mu tat. Res., 5, 665-671 Sasakawa, S. Mitomi, Y. (1978) Di-2-ethylhexyl phthalate (DEHP) content of blood or blood components stored in plastic bags. Vox Sang., 34, 81-86 Saxena, D.K., Srivastava, S.P, Chandra, S.V. Seth, P.K. (1985) Testicrrlar effects of di-(2-ethylhexyl) phthalate (DEHP) histochemical and histopathological alteratiorrs. Ind. Health, 23, 191-198... [Pg.143]

Ethylbenzene was non-mutagenic in bacteria, yeast and insects. In mammalian cells, it was inactive in inducing sister chromatid exchanges in Chinese hamster embryo cells but very weakly positive in cultured human l5miphocytes. It did not induce micronuclei in vivo, although it was positive in Syrian hamster embryo cells in vitro. It also caused cell transformation in these cells. Ethylbenzene induced mutations in the mouse lymphoma assay, but only at the highest non-lethal concentration tested. [Pg.257]

Gibson, D.R, Brauninger, R., Shaffi, H.S., Kerckaert, GA., LeBoeuf, R.A., Isfort, R.J. Aardema, M.J. (1997) Induction of micronuclei in Syrian hamster embryo cells comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals. Mutat. Res., 392, 61-70... [Pg.261]

Kerckaert, G.A., LeBoeuf, R.A. Isfort, R.J. (1998) Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds. Toxicol. Sci., 41, 189-197... [Pg.311]

Sanner, T. Rivedal, E. (1985) Tests with the Syrian hamster embryo (SHE) cell transformation assay. In Ashby, J., de Serres, F.J., Draper, M., Ishidate, M., Jr, Margolin, B.H., Matter, B.E. Shelby, M.D., eds, Progress in Mutation Research, blume 5, Evaluation of Short-Term Tests for Carcinogens. Report of the International Programme on Chemical Safety s Collaborative Study on in vitro assays, Amsterdam, Elsevier Science, pp. 665-671 Savela, A., Vuorela, R. Kauppinen, T. (1999) ASA 1997 [Reviews 140], Helsinki, Finnish Institute of Occupational Health, pp. 47-48 (in Finnish)... [Pg.318]

LeBoeuf RA, Kerchaert GA, Aardema MJ, et al. 1996. The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. Mutat Res 356 85-127. [Pg.437]

Barrett, J. C. Lamb, P. W. (1985) Tests with the Syrian hamster embryo cell transformation assay. Prog. Mutat. Res., 5, 623-628... [Pg.93]

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