Pharmacogenomics

Over the last few years, pharmacogenomic studies have become an increasingly greater part of drug development. As Lesko and Woodcock (2005) noted [Pg.227]

The practice of precision medicine is predicated on knowledge of a person s genotype. The term precision medicine is deliberately used here instead of other common terms such as personalized medicine and individualized medicine Clinicians, as they will argue forcefully and very reasonably, have always practiced [Pg.227]

B rinkmann U, Eichelbaum M (2001) Polymoiphisms in the ABC drug tianspoiter gene MDR1. Pharmacogenomics J 1 59-64... [Pg.8]

Discovery of new diagnostic and prognostic indicators and biomarkers of therapeutic response, and prediction of patients most likely to benefit from the diug and use in general pharmacogenomic studies (Fig. 2)... [Pg.528]

Pharmacogenetics and Pharmacogenomics (2000) Recent Conceptual and Technical Advances. Pharmacology 61(3) (the entire issue)... [Pg.951]

Licinio J, Wong ML (ed) (2002) Pharmacogenomics The search for individualized therapies. Wiley-VCH/John Wiley, Weinheim... [Pg.951]

The reader is also referred to a number of journals specifically devoted to this field of research Pharmacogenetics published by Lippincott Williams and Wilkins Pharmacogenomics published by Ashley Publications Ltd. American Journal of Pharmacogenomics published by ADIS international The Pharmacogenomics Journal published by Nature Publishing group... [Pg.951]

The prerequisite of the relatively new disciplines pharmacogenetics/pharmacogenomics is that individuals... [Pg.951]

As pharmacogenetics and pharmacogenomics are not mutually exclusive, but even sometimes display overlapping features, both disciplines are aimed at better tailoring medical therapy for a given complex disease such as essential hypertension or other CVD. In the wake of new technologies to identify candidate region for whatever phenotype, more robust and complex bioinformatic analyses are necessary to... [Pg.953]

Staessen JA, Kuznetsova T, Acceto R et al (2005) OASIS-HT design of a pharmacogenomic dose-finding study. Pharmacogenomics 6 755-775... [Pg.954]

Schmitz G, Langmann T (2006) Pharmacogenomics of cholesterol-lowering therapy. Vascul Pharmacol 44(2) 75-89... [Pg.1160]

El 4 The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs Pharmacogenomics... [Pg.80]

Wadelius, M. and Pirmohamed, M. (2007). Pharmacogenetics of warfarin current status and future challenges. Pharmacogenomics Journal 7, 99-111. [Pg.372]

We proposed the term psychoneurogenic for the mechanism of these reactions, since the direct action on the nerve might elicit a reflex cascade via the CNS and then lead to the above-mentioned symptoms. Why these reactions only occur in certain individuals, maybe due to pharmacogenomics and specific hyperexcitability of peripheral nerves, remains open for speculation. There is a high degree of psychosomatic involvement in such reactions. [Pg.194]

Gunther EC, Stone DJ, Rothberg JM, Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. Pharmacogenomics J 2005 5 126-34. [Pg.160]

Young SS, Ge N. Recursive partitioning analysis of complex disease pharmacogenetics studies. I. Motivation and overview. Pharmacogenomics 2005 6(1) 65-75. [Pg.441]

Zaykin DV, Young SS. Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations. Pharmacogenomics 2005 6(l) 77-89. [Pg.441]

Weinshilboum R, Wang L. Pharmacogenomics bench to bedside. Nat Rev Drug Discov 2004 3 739-48. [Pg.524]

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