Pharmacogenomics genes

Advances in measurement of gene expression have also been phenomenal. In five years, the numbers of genes, sensitivity of the assays, and reproducibility of results have also increased significantly as has the ability to analyze the data. The measurement of gene expression has been used in several ways in cancer genetics and cancer pharmacogenomics. Gene expression has led to better ways to classify cancers and to select the appropriate therapy (Miyazato et al., 2001 Birner et al., 2001). 

B rinkmann U, Eichelbaum M (2001) Polymoiphisms in the ABC drug tianspoiter gene MDR1. Pharmacogenomics J 1 59-64... 

New information has been added in appropriate chapters on hpid rafts and caveolae, aquaporins, connexins, disorders due to mutations in genes encoding proteins involved in intracellular membrane transport, absorption of iron, and conformational diseases and pharmacogenomics. 

Xing, Q. et al. (2006b). Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics, 7, 987-93. 

Lee, H.-J., Cha, J.-H., Ham, B.-J. etal. (2004). Association between a G-protein boldbeta3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J., 4, 29-33. 

Fuke, S., Suo, S., Takahashi, N., Koike, H., Sasagawa, N., and Ishuiri, S., The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression, Pharmacogenom. J., 1,152,2001. 

Brinkmann, U., Eichelbaum, M., Polymorphisms in the ABC drug transporter gene MDR1, Pharmacogenomics J. 2001, 3, 59-64. 

Perhaps the oldest and most well-studied class of pharmacogenomic markers are the drug metabolizing enzymes. These include variants in genes which encode... 

Pharmacogenomic studies are often carried out in the context of clinical trials which, by virtue of having both a treatment and placebo group, are able to assess the association between a gene and disease progression independent of therapy as well as interactive effects of genotypes and therapy on disease. Several of the phar-... 

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