Prognostic indicators

A measurable DNA/RNA or protein characteristic that is an indicator of normal biological process, pathogenic process and/or response to therapeutic or other inventions, used as diagnostic and prognostic indicators. 

Discovery of new diagnostic and prognostic indicators and biomarkers of therapeutic response, and prediction of patients most likely to benefit from the diug and use in general pharmacogenomic studies (Fig. 2)... 

HA ART, since the time to suppression of viremia has been identified as an important prognostic indicator (Louie et al. 2003 Polis et al. 2001). 

What are some possible causes of respiratory failure and hypotension in this patient Are these findings poor prognostic indicators ... 

M10. Marecaux, G., Pinsky, M. R., Dupont, E., Kahn, R. J., and Vincent, J. L., Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock. Intensive Care Med. 22,404-408 (1996). 

D5. Duffy, M. J., Biochemical markers as prognostic indices in breast cancer. Clin. Chem. (Winston-Salem. NC) 36, 188-191 (1990). 

The long-term course of BN remains unclear. In addition, reliable prognostic indicators are uncertain. It does appear, however, that for many patients the disorder... 

A retrospective analysis of anemia as a prognostic indicator and its impact on the efficacy of radiotherapy has been recently published. Patients who received concomitant cisplatin (150 mg/m2/wk for 4 wk) and radiotherapy (RADPLAT protocol) for stage III or IV HNC were found to have less treatment interruptions, decreased locoregional failure, and improved overall survival if not anemic (95). 

Sohn TA, et al. Resected adenocarcinoma of the pancreas-616 patients results, outcomes, and prognostic indicators. J Gastrointest Surg 2000 4(6) 567-579. 

Dong M, Nio Y, Guo KJ, et al. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1998 18 4613-4619. 

G. Gasparini, P.C. Brooks, E. Biganzoli, P.B. Vermeulen, E. Bonoldi, L.Y. Dirix, G. Ranieri, R. Miceli, D.A. Cheresh, Vascular integrin alpha(v)beta3 A new prognostic indicator in breast cancer, Clin. Cancer Res. 4(11) (1998) 2625-2634. 

The illness variables that were predictive of poor outcome all reflected severity of illness. They included more severe panic and agoraphobic symptoms, psychiatric hospitalization, and longer duration of illness. The best prognostic indicators were the severity of the illness and its duration at the time of first assessment. Comorbid depression was also associated with poorer outcome. A number of environmental variables were also predictive of poor outcome separation from a parent by death or divorce, high interpersonal sensitivity, low social class, and unmarried marital status. 

Yu H, Giai M, Diamandis EP, et al. Prostate-specific antigen is a new favorable prognostic indicator for women with breast cancer. Cancer Res 1995 55 2104-2110. 

Fruhwald MC. DNA methylation patterns in cancer novel prognostic indicators . Am J Pharmacogenomics 2003 3 245-260. 

SK Gupta, M Aziz, AA Khan (1989) Serum leucine aminopeptidase estimation a sensitive prognostic indicator of invasiveness in breast carcinoma, Indian J Pathol Microbiol 32 301—305... 

Male fetuses with 50 to 230 copies of the repeat should be asymptomatic, whereas those with more than 230 copies will have fragile X syndrome. Female fetuses with 50 to 230 copies also will be asymptomatic however, it is difficult to predict the extent of mental retardation in female fetuses with more than 230 copies of the repeat. Although hypermethylation of the CpG island is a poor prognostic indicator, it is not always present in DNA extracted from chorionic villus samples (Sutherland et al., 1991). Empiric data showing that female carriers with full mutations have nearly a 50% risk of mental impairment should be considered reliable. 

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