Pharmacogenomic analyses

Gould Rothberg BE. The use of animal models in expression pharmacogenomics analyses. Pharmacogenomics J 2001 1 48-58. 

Several other chapters in this book address ethical issues, which are essential for the educational programs. Pharmacogenomic analyses will multiply the challenges of explaining available tests and gaining informed consent to perform each test. In some cases, patients or relatives will be asked... 

A major goal of pharmacogenetic and pharmacogenomic analyses in early-phase clinical studies is to identify subpopulations of subjects with an improved safety and efficacy profile. However, there are various views on how pharmacogenetics and pharmacogenomics could be used in the design of clinical trials. Some examples are as follows ... 

Tab. 3.3 Examples of study designs used for pharmacogenomic analysis...

The pharmacogenomics analysis of samples from a clinical study with an aluminum hydroxide-adsorbed vaccine (diphtheria-tetanus-acellular pertussis/polio/ Haemophilus influenzae) in infants is described. These instructions can easily be adapted to clinical studies of other vaccines with changes to the type of administered vaccine, administration route, vaccination ages, and so on. This method is therefore also suitable for assessing vaccine responses in adults and to study the cellular reactions in clinical subjects who have experienced adverse reactions. 

Blower PE, Yang C, Fligner MA et al. Pharmacogenomic analysis correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J2002(2-.259-271. 

McClay JL, Adkins DE, Aberg K, Stroup S, Perkins DO, Vladimirov VI et al (2011) Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry 16 76-85... 

Blower, P.E., Yang, C., Fligner, M.A., Verducci, J.S., Yu, L., Richman, S., and Weinstein, J.N. 2002. Pharmacogenomic analysis Correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J 2 259-271. 

Gunther EC, Stone DJ, Rothberg JM, Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. Pharmacogenomics J 2005 5 126-34. 

Young SS, Ge N. Recursive partitioning analysis of complex disease pharmacogenetics studies. I. Motivation and overview. Pharmacogenomics 2005 6(1) 65-75. 

Zaykin DV, Young SS. Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations. Pharmacogenomics 2005 6(l) 77-89. 

Ishikawa, T., Onishi, Y., Hirano, H. et al. (2004). Pharmacogenomics of drug transporters a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDRl). Biol. Pharm. Bull., 27, 939 48. 

Figure 3.1 illustrates the concept of haplotypes. The most accurate methods for determining haplotypes are experimental ones involving laborious and expensive laboratory analysis [44—46]. Alternatively, accuracy can sometimes be achieved by genotyping additional family members [47]. In pharmacogenomic studies where... 

---