Pharmacogenomics of Drug Transport

Saier et al. (134-137) have developed a system of transporter classification (T.C. number) analogous to the Lnzyme Commission (L.C. number) system for uniquely identifying enzymes. Transporters are organized as follows  

Lach transporter is assigned a unique identifier, for example, T.C. W.X.Y.Z. In the system, two proteins 

In another example, real-time polymerase chain reaction (RT-PCR) was used to determine expression levels of the 48 known human ABC-type transporters in the NCI-60 cell lines, and these levels were correlated with sensitivity to 1429 candidate anticancer drugs (149, 150). Patterns of expression correlated moderately well with tissue of origin and were independent of sequence homology among 

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Ishikawa, T., Onishi, Y., Hirano, H. et al. (2004). Pharmacogenomics of drug transporters a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDRl). Biol. Pharm. Bull., 27, 939 48. 

Lee VH, Sporty JL, Fandy TE. Pharmacogenomics of drug transporters The next drug delivery challenge. Adv Drug Deliv Rev 2001 50(suppl 1) S33—40. 

Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy... 

Ishikawa T, Tsuji A, Inui K, Sai Y, Airzai N, Wada M et al. The genetic polymorphism of drug transporters Functional analysis approaches. Pharmacogenomics 2004 5 67-99. 

Sparreboom A, Danes R, Ando Y, Chan J, Figg WD. Pharmacogenomics of ABC transporters and its role in cancer chemotherapy. Drug Resist Updat 2003 6 71-84. 

Kiyotani K et al (2012) Pharmacogenomics of tamoxifen roles of drug metabolizing enzymes and transporters. Drug Metab Pharmacokinet 27(1) 122—131... 

Tirona RG, Kim RB. Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv Drug Deliv Rev 2002 54 1343-52. 

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