Pharmacogenomics of Leukotrienes in Asthma

This hypothesis was investigated in a retrospective analysis of the response to an ALOX5 inhibitor, ABT-761, which is clinically similar to zileuton. In 221 patients with asthma who received either high-dose ABT-761 (n= 114) or placebo (n= 107] treatment, approximately 6% of asthmatic patients had no wild-type allele 

Sampson and colleagues found that, among asthmatic subjects treated with zafirlukast (20 mg bid), those homozygous for the A allele (n=10 subjects) at the -444 locus had a lower FEVx response than those with the C/C or C/A (n=13) geno- 

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