Pharmacogenomics defined

It is important to realize, that diseases such as myocardial infarction or type 2 diabetes represent a heterogeneous group of several distinct subphenotypes definable by clinical or biochemical characteristics. Thus, contradictory findings in pharmacogenomic studies may only not be the consequence of a lack of a major isolated gene effect (of the gene variant studied) and chance findings, but also be caused by the variability in the mix of distinct clinical phenotypes hidden beneath a common characterization such as type 2 diabetes and modulated by differences in the environment between studies. 

What are the ethical, legal, social, and scientific implications of pharmacogenomics Given the current disparities and the role—however illegitimate—of skin color and ethnicity in the distribution of medical services, how might new approaches to therapy affect socially defined groups of African, Asian, and Hispanic descent These questions are complex individually, and they become more so when intersected. 

The information about allele frequency in an anthropologically defined human population is important for pharmacogenomics studies as different population... 

Ansari, M., and Krajinovic, M. (2007) Pharmacogenomics in cancer treatment defining genetic bases for inter-individual differences in responses to chemotherapy. Curr. Opin. Pediatr. 19, 15-22. 

Risner ME, Saunders AM, Altman IF et al. Effieaey of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer s disease. Pharmacogenomics J 2006 6 246-254. 

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