Pharmacogenomics analysis

Tab. 3.3 Examples of study designs used for pharmacogenomic analysis...

The pharmacogenomics analysis of samples from a clinical study with an aluminum hydroxide-adsorbed vaccine (diphtheria-tetanus-acellular pertussis/polio/ Haemophilus influenzae) in infants is described. These instructions can easily be adapted to clinical studies of other vaccines with changes to the type of administered vaccine, administration route, vaccination ages, and so on. This method is therefore also suitable for assessing vaccine responses in adults and to study the cellular reactions in clinical subjects who have experienced adverse reactions. 

Blower PE, Yang C, Fligner MA et al. Pharmacogenomic analysis correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J2002(2-.259-271. 

McClay JL, Adkins DE, Aberg K, Stroup S, Perkins DO, Vladimirov VI et al (2011) Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry 16 76-85... 

Blower, P.E., Yang, C., Fligner, M.A., Verducci, J.S., Yu, L., Richman, S., and Weinstein, J.N. 2002. Pharmacogenomic analysis Correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J 2 259-271. 

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