Pharmacogenomics association studies

Ziv, E., and Burchard, E.G. (2003) Human population structure and genetic association studies. Pharmacogenomics. 4, 431-441. 

Because common SNPs are phylogenetically older than rare SNPs, they have arisen from recombination events of ancestral haplotypes (3). Focusing on these common SNPs will thus allow reconstruction of these ancestral haplotypes so that human evolutionary history can be traced. Most important, however, is the fact that using common SNPs to map the structure of human haplotypes will allow identification of haplotypes that constitute the majority (perhaps as much as 90%) of human variation and hence will be the most informative source available for disease and pharmacogenomic association studies. 

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