Pharmacogenomics, concepts

Figure 3.1 illustrates the concept of haplotypes. The most accurate methods for determining haplotypes are experimental ones involving laborious and expensive laboratory analysis [44—46]. Alternatively, accuracy can sometimes be achieved by genotyping additional family members [47]. In pharmacogenomic studies where... 

Basic Concepts Underlying the Pharmacogenomics of the Blood-Brain Barrier... 

Basic Concepts Underlying the Pharmacogenomics of the Blood-Brain Barrier 317 15.1.2.3 Astrocytes in the Blood-Brain Barrier... 

By covering topics from individnal molecnles to systemic diseases, from fundamental concepts to advanced technologies, this book intends to provide a practical, state-of-the-art, and integrative view of the application of pharmacogenomics in drug discovery and development. I wonld like to thank aU of the anthors for their contribntions to this exciting new field. I also thank the series editor, Dr. John Walker, for his help with the editing. 

A notable application of pharmacogenomics in early phase drug development, which extends beyond personalized medicine, is in proof-of-concept investigations. Phase 2A/2B trials enriched for patients with certain genetic subtypes of drug targets previously shown to confer an increased likelihood of response can facilitate decisions on whether and to what extent a NME is a viable therapeutic candidate. Conversely, an inadequate response to a NME in such enriched samples may serve as an early indication of possible therapeutic failure in the general patient population. 

Shastry BS (2006) Pharmacogenetics and the concept of individualized medicine. Pharmacogenomics J 6 16-21... 

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