Pharmacogenomics gene expression

Advances in measurement of gene expression have also been phenomenal. In five years, the numbers of genes, sensitivity of the assays, and reproducibility of results have also increased significantly as has the ability to analyze the data. The measurement of gene expression has been used in several ways in cancer genetics and cancer pharmacogenomics. Gene expression has led to better ways to classify cancers and to select the appropriate therapy (Miyazato et al., 2001 Birner et al., 2001). 

Fuke, S., Suo, S., Takahashi, N., Koike, H., Sasagawa, N., and Ishuiri, S., The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression, Pharmacogenom. J., 1,152,2001. 

Regnstrom, K., Ragnarsson, E.G.E., Rydell, N., Sjoholm, I., and Artursson, P. (2002) Tetanus antigen modulates the gene expression profile of aluminum phosphate adjuvant in spleen lymphocytes in vivo. Pharmacogenomics J. 2, 57-64. 

Kita Y, Shiozawa M, Jin W et al 2002 Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics 12 55-65... 

Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK (1999) Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 88 61-66 Hahn MK, Blakely RD (2002) Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J 2 217-235 HeUs A, Teufel A, Petri S, et al (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66 2621-2624... 

Blower PE, Yang C, Fligner MA et al. Pharmacogenomic analysis correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J2002(2-.259-271. 

Fig. 2. Regulation of thymidylate synthase (TS) gene expression. Abbreviations.- TS (thymidylate synthase) USF-1 (upstream stimulating factor 1) USF-2 (upstream stimulating factor 2) SNP (single nucleotide polymorphism). (Reprinted with permission of El-Khoueiry et al. Pharmacogenomics and molecular biology of gastrointestinal cancers, Atlas of Gastrointestinal Cancers, Current Medicine Group, LLC, Philadelphia, 2007).

Developing Empirical Pharmacogenomic Classifiers Using Gene Expression Developmental and Validation Studies Estimates of Predictive Accuracy in Developmental Studies Use of Pharmacogenomic Classifiers in New Drug Development Conclusions Acknowledgements References... 

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