Pharmacogenomics genotyping

Jannetto P J, Laleli-Sahin E, Wong S H (2004). Pharmacogenomic genotyping methodologies. Clin. Chem. Lab. 42 1256-1264. 

Pharmacogenomics The science of understanding the correlation between an individual patient s genetic make-up (genotype) and their response to drug treatment. 

Figure 3.1 illustrates the concept of haplotypes. The most accurate methods for determining haplotypes are experimental ones involving laborious and expensive laboratory analysis [44—46]. Alternatively, accuracy can sometimes be achieved by genotyping additional family members [47]. In pharmacogenomic studies where... 

Pharmacogenomic studies are often carried out in the context of clinical trials which, by virtue of having both a treatment and placebo group, are able to assess the association between a gene and disease progression independent of therapy as well as interactive effects of genotypes and therapy on disease. Several of the phar-... 

Drazen JM, Yandava CN, Dube L, SzCZERBACK N, HlPPENSTEEL R, PlLLARI et al. Pharmacogenomic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet 1999 22 168-170. 

Research underway by our group and others on the clinical pharmacogenomics of depression is focused on identifying genetic markers as positive and negative predictors of treatment response. It is necessary that rigorous clinical studies be performed in order to examine closely the relation between genotype and the phe-... 

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