Precision Medicine

The practice of precision medicine is predicated on knowledge of a person s genotype. The term precision medicine is deliberately used here instead of other common terms such as personalized medicine and individualized medicine Clinicians, as they will argue forcefully and very reasonably, have always practiced... 

Keywords CT MRI PET SPECT Ultrasound imaging Personalized medicine Precision medicine Physiologic imaging Molecular imaging... 

Marquet, P., Longeray, P.H., Barlesi, F., Ameye, V., Auge, P., Cazeneuve, B., et al. Translational research precision medicine, personalized medicine, targeted therapies marketing or science Therapie 70(1), 11-19 (2015)... 

National Research Council CommitteeToward Precision Medicine Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, National Academies Press, Washington DC, (2011). 

Fernando Martin Sanchez holds PhDs in informatics and in medicine. He is chair of Health Informatics at the University of Melbourne, Melbourne, Australia, and the director of the university s Health and Biomedical Informatics Centre. He has more than 100 peer-reviewed publications and his research has been funded by some 30 grants from the European Commission the Spanish Ministries of Health, Science, and Defense and the Australian National Health and Medical Research Coimcil, the Institute for a Broadband Enabled Society, and Department of Health and Ageing. His research interests cover a wide range of topics related to the role of informatics in precision medicine (genomics and exposomics) and participatory health (social media, quantified-self, and mobile apps and devices). 

Six areas are discussed. While these have been chosen arbitrarily, each one allows additional commentary on the general topic of drug safety. These areas include regulatory science, rare diseases, precision medicine, pain medication, adherence, and the reporting of randomized clinical trials. 

While the term personalized medicine is used widely in the literature to refer to the tailoring of an intervention for an individual based on specific (often genetic) information pertaining to that individual, in almost all cases, the term precision medicine... 

Amable L (2016) Cisplatin resistance and opportunities for precision medicine. Pharmacol Res 106 27-36... 

Arnedos M, Vicier C, Loi S et al (2015) Precision medicine for metastatic breast cancer limitations and solutions. Nat Rev Qin Oncol 12 693-704. Jul 21 Auffray C, Caulfield T, Griffin JL et al (2016) From genomic medicine to precision medicine highlights of 2015. Genome Med 8 12... 

Bermejo-Martin JF, Andaluz-Ojeda D, Almansa R et al (2016) Defining immunologictil dysfunction in sepsis a requisite tool for precision medicine. J Infect 72(5) 525-536 Bu LL, Yang K, Xiong WX et al (2016) Toward precision medicine in Parkinson s disease. Ann... 

Heckman-Stoddard BM, Smith JJ (2014) Precision medicine clinical trials defining new treatment... 

Irwin MS, Park JR (2015) Neuroblastoma paradigm for precision medicine. Pediatr Clin North... 

Montine TJ, Montine KS (2015) Precision medicine clarity for the clinical and biological complexity of Alzheimer s and Parkinson s diseases. J Exp Med 212 601-605 Ortega VE, Meyers DA, Bleecker ER (2015) Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med 8 9-22 Prados MD, Byron SA, Tran NL et al (2015) Toward precision medicine in glioblastoma the promise and the challenges. Neuro Oncol 17 1051—1063... 

Roper N, Stensland KD, Hendricks R, Gaisky MD (2015) The landscape of precision cancer medicine clinical trials in the United States. Cancer Treat Rev 41 385-390 Williams JK, Katapodi MC, Starkweather A et al (2016) Advanced nursing practice and research contributions to precision medicine. Nurs Outlook 64 117-123 Woodcock J (2016) Precision drug development Qin Pharmacol Ther 99 152-154 Zou ZY, Liu CY, Che CH, Huang HP (2016) Toward precision medicine in amyotrophic lateral sclerosis. Ann Transl Med 4 27... 

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