Pharmacogenomics, computers

The science of microbial genomics requires special attention, in part, because of its medical and economic importance. Even more so, microbial genomics provide important lessons for all of computational biology and comparative genomics, and therefore, microbial genomes are prototypes for the future of pharmacogenomics. 

Handling such interwoven networks and complex feedback loops is beyond the capability of common laboratory methods, not to mention that just the complexity of scientific literature itself is already beyond measure. Help from computers and bioinformatics has become a must in today s biomedical research. In fact, bioinformatics methods have become indispensable for each step in biomedical research, from high-throughput data collection to clinical decision support. This chapter focuses on the application of bioinformatics methods in the study of pharmacogenomics, drug discovery, and systems biology. 

Chapter 13—Pharmacogenomics Kermani discusses the scientific and computational challenges of pharmacogenomics and how personalized medicine has several sociological obstacles to overcome before it becomes a mainstay diagnostic for medical therapies. 

Key Words High-performance computing pharmacogenomic information infrastructure database database management system software architecture hardware architecture web service data warehouse federated database system parallel processing data storage. 

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