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Paclitaxels

Synthesis of paclitaxel and resiniferatoxin analogs, diterpenoids with oxetane fragments 97G461. [Pg.240]

A higher than expected incidence of CHF is also observed in patients treated with DOX and other cytotoxics (e.g., the taxane paclitaxel) or new generation targeted agents (e.g., the humanized anti-ErbB-2/neu monoclonal antibody trastuzumab) [3]. The cardiotoxic synergism of DOX with taxanes or... [Pg.94]

Taxanes (paclitaxel, docetaxel) are derivatives of yew tree bark (Taxus brevifolia). They stabilize microtubules in the polymerized state leading to nonfunctional microtubular bundles in the cell. Inhibition occurs during G2- and M-phases. Taxanes are also radiosensitizers. Unwanted effects include bone marrow suppression and cumulative neurotoxicity. [Pg.155]

Ranganathan S, Benetatos CA, Colamsso PJ et al (1998) Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells. Br J Cancer 77 562-566... [Pg.417]

Mitotic inhibitors (antimitotics) interfere with or stop cell division. Examples of mitotic inhibitors include paclitaxel (Taxol) and vincristine (Oncovin). [Pg.592]

F.14 Paclitaxel, which is extracted from the Pacific yew tree Taxus brevifolia, has antitumor activity for ovarian and breast cancer. It is sold under the trade name Taxol. On analysis, its mass percentage composition is 66.11% C, 6.02% H, and 1.64% N, with the balance being oxygen. What is the empirical formula of paclitaxel ... [Pg.75]

High pressure cycloaddition of cytraconic anhydride (140) with 2-substituted furans 142 afforded, cxo-diastereoselectively but unregioselectively, bicyclic cycloadducts 143 and 144 that have been used in straightforward routes to CD-ring fragment of paclitaxel [55] (Scheme 5.22). The cycloadducts were then... [Pg.231]

C2H3BrO 506-96-7) see Paclitaxel N-acetyl-2 -bromo-2 -deoxycytidine 3, S -diacetate (C 5HigBrN307 126430-12-4) see Zalcitabine A -acetyl-3 -bromo-3 -deoxycytidine 2, 5 -diacetate (C 5H gBrN307 126430-11-3) see Zalcitabine 2-acetyl-4-butyramidophenol (C 2H,5N03 40188-45-2) see Acebutolol... [Pg.2283]

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... [Pg.2283]

C7H )N2 1122-58-3) see Paclitaxel Zafiilukast 4-dimethylamino-3-(4-pyridyl)-3-bulen-2-one (CHH14N2O 7 504 61-7) see Milrinone 2-dimethylaminosulfunylphenothiazine... [Pg.2362]

ChH, N20 1659-31-0) see Paclitaxel l-(2 (i-dipyrrolidino-4-pyrimidinyl)pipera7jne (C f,H2(iN(5 111641-17-9) see Tirilazad mesilate S)-l, 4-dithia-7-azaspiro[4.4)nonane-S carboxylic acid hydrobromide... [Pg.2370]

C4H,0, 623-50-7) see Paclitaxel 13-ethylgona-5(10),15-diene-3,17-dione cyclic 3-(2,2-di-methyl-l,3-propanediyl acetal)... [Pg.2380]

C5H9NO 10431-98-8) see Nefazodone hydrochloride ( )-ethyl 2-oxo-3-benzoylamino-3-phenylpropionate (C H,7N04 153433-79-5) see Paclitaxel ethyl 3-oxocaproatc... [Pg.2383]

C20H2JNO3 3608-67-/) see Propiverine (-)-(lS,2S)-/V-(2-hydroxy-l-phenyl-3-butenyl)benzamide (C17H17NO2 136693-02-2) see Paclitaxel [hydroxy(4-phenylbutyl)phosphinyl]acetic acid phenylmc-thyl ester... [Pg.2399]


See other pages where Paclitaxels is mentioned: [Pg.55]    [Pg.56]    [Pg.58]    [Pg.77]    [Pg.355]    [Pg.487]    [Pg.494]    [Pg.416]    [Pg.638]    [Pg.1196]    [Pg.1271]    [Pg.231]    [Pg.1545]    [Pg.1546]    [Pg.1547]    [Pg.1548]    [Pg.1549]    [Pg.1550]    [Pg.2280]    [Pg.2282]    [Pg.2287]    [Pg.2287]    [Pg.2301]    [Pg.2302]    [Pg.2302]    [Pg.2303]    [Pg.2305]    [Pg.2311]    [Pg.2320]    [Pg.2342]    [Pg.2369]    [Pg.2376]    [Pg.2385]    [Pg.2399]    [Pg.2406]    [Pg.2406]   
See also in sourсe #XX -- [ Pg.524 ]

See also in sourсe #XX -- [ Pg.262 , Pg.290 , Pg.311 ]

See also in sourсe #XX -- [ Pg.524 ]

See also in sourсe #XX -- [ Pg.98 , Pg.524 ]




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10-Deacetyl paclitaxel

Albumin-bound paclitaxel metastatic breast cancer

Alopecia paclitaxel

Amifostine Paclitaxel

Aprepitant Paclitaxel

Arthralgia paclitaxel

Biosynthetic paclitaxel

Brain tumors paclitaxel

Butyl paclitaxel analog

Cancer paclitaxel

Capecitabine Paclitaxel

Carboplatin Paclitaxel

Cardiac dysrhythmias paclitaxel

Cisplatin combination with paclitaxel

Cisplatin/paclitaxel

Cremophor Paclitaxel

Cyclophosphamide Paclitaxel

DHA-paclitaxel

Dexamethasone Paclitaxel

Discovery of Paclitaxel

Docosahexaenoic acid DHA) paclitaxel

Docosahexaenoic acid paclitaxel

Doxorubicin Paclitaxel

Drugs paclitaxel

Epirubicin Paclitaxel

Esophageal cancer paclitaxel

Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore

Fungi, paclitaxel from

Gastrointestinal cancer paclitaxel

Gemcitabine Paclitaxel

HPMA copolymer-paclitaxel

Head cancers paclitaxel

Hormonal) Paclitaxel

Ifosfamide Paclitaxel

Indinavir Paclitaxel

Manufacturing of Paclitaxel

Melanoma paclitaxel

Methyl paclitaxel analog

Microtubules paclitaxel

Mucositis paclitaxel

Myalgia paclitaxel

Nanoparticle paclitaxel micellar

Neck cancers paclitaxel

New Antimicrotubule Molecules Mimicking Action of Paclitaxel

Nonsmall-cell lung cancer paclitaxel

Numbness paclitaxel

Other Anticancer Agents Paclitaxel

Other Biological Actions of Paclitaxel

Oxygen Paclitaxel

PEG-paclitaxel

Paclitaxel

Paclitaxel (Taxol

Paclitaxel , discodermolide

Paclitaxel 6a-hydroxylation

Paclitaxel 7-ethers

Paclitaxel Carbamazepine

Paclitaxel Ciclosporin

Paclitaxel Cimetidine

Paclitaxel Cyclosporine

Paclitaxel Diphenhydramine

Paclitaxel Isolation

Paclitaxel Ketoconazole

Paclitaxel Methotrexate

Paclitaxel Nelfinavir

Paclitaxel Paclitaxels

Paclitaxel Phenobarbital

Paclitaxel Phenytoin

Paclitaxel Protease inhibitors

Paclitaxel Ritonavir

Paclitaxel adverse effects

Paclitaxel albumin bound

Paclitaxel analogs

Paclitaxel analogs active against normal tumor cells

Paclitaxel analogs synthesis

Paclitaxel and Docetaxel

Paclitaxel and cisplatin

Paclitaxel and radiation

Paclitaxel anemia

Paclitaxel anticancer

Paclitaxel anticancer drug

Paclitaxel antitumor natural product

Paclitaxel biological actions

Paclitaxel biosynthesis

Paclitaxel biosynthetic pathway

Paclitaxel bone-marrow suppression

Paclitaxel bradycardia

Paclitaxel breast cancer

Paclitaxel bundles

Paclitaxel camptothecin

Paclitaxel chemical structure

Paclitaxel coated stent

Paclitaxel concentration

Paclitaxel conformation, differences

Paclitaxel conformational analysis

Paclitaxel conjugate

Paclitaxel cytotoxicities

Paclitaxel damage

Paclitaxel dendrimers

Paclitaxel diarrhea

Paclitaxel dosage

Paclitaxel drug interactions

Paclitaxel drug-eluting vascular stents

Paclitaxel dysrhythmias

Paclitaxel electron crystallography

Paclitaxel encapsulation

Paclitaxel extraction

Paclitaxel extravasation

Paclitaxel fluorescent derivatives

Paclitaxel fluorine-containing analog

Paclitaxel from Microorganisms

Paclitaxel gastric cancer

Paclitaxel gynecological cancer

Paclitaxel hepatic metabolism

Paclitaxel hypersensitivity

Paclitaxel hypersensitivity docetaxel

Paclitaxel hypersensitivity taxanes

Paclitaxel hypotension

Paclitaxel in ovarian cancer

Paclitaxel infusion, prolonged

Paclitaxel interactions

Paclitaxel lead compound development

Paclitaxel leukemia

Paclitaxel lung cancer

Paclitaxel mechanism studies

Paclitaxel metabolism

Paclitaxel microtubule blocking

Paclitaxel molecular modeling

Paclitaxel myocardial infarction

Paclitaxel nanoparticles

Paclitaxel neutropenia

Paclitaxel orally administered

Paclitaxel ovarian cancer

Paclitaxel peripheral neuropathy

Paclitaxel pharmacokinetic

Paclitaxel pharmacokinetics

Paclitaxel pharmacology

Paclitaxel plant cell fermentation

Paclitaxel pneumonitis

Paclitaxel prodrugs

Paclitaxel progressive disease

Paclitaxel purification

Paclitaxel receptors

Paclitaxel recurrent

Paclitaxel renal function

Paclitaxel resistance

Paclitaxel semi-synthetic production from

Paclitaxel semisynthesis

Paclitaxel side chain production

Paclitaxel small-cell lung carcinoma

Paclitaxel structure

Paclitaxel studies

Paclitaxel synthesizing

Paclitaxel therapy

Paclitaxel thrombocytopenia

Paclitaxel toxicity

Paclitaxel tubulin binding mechanism

Paclitaxel, adverse reactions

Paclitaxel, anticancer agent

Paclitaxel, chemical synthesis

Paclitaxel, detection

Paclitaxel, liposomal encapsulation

Paclitaxel, origin

Paclitaxel, polymer formulation

Paclitaxel, polymer formulation containing

Paclitaxel, solubilization

Paclitaxel, synthesis

Paclitaxel-camptothecin analogs

Paclitaxel-induced apoptosis

Paclitaxel-loaded polymer

Paclitaxel-resistant tumors

Paclitaxel-tubulin binding

Paclitaxel/epothilone pharmacophore

Paclitaxel/epothilone pharmacophore model

Paclitaxels synthesis

Pharmaceutical industry paclitaxel

Pharmaceuticals paclitaxel

Poly paclitaxel

Poly paclitaxel conjugate

Poly paclitaxel incorporation into

Polymers Used for Paclitaxel Stents

Prostate cancer, polymer-paclitaxel

Prostate cancer, polymer-paclitaxel formulation

Solvent paclitaxel processes

Stomatitis paclitaxel

Taxanes paclitaxel

Taxol (Paclitaxel) and Cancer Chemotherapy

Taxus paclitaxel-eluting controlled drug delivery system

The BMS Paclitaxel Process

Three Selected Synthetic Transformations on the Pathway to Paclitaxel

Trastuzumab/paclitaxel

Tumor cells, paclitaxel analogs active against

Vomiting paclitaxel

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