Paclitaxel renal function

PACLITAXEL CISPLATIN t risk of profound neutropenia Prior administration of cisplatin tends to impair renal function and 1 clearance of paclitaxel by approximately 25% Advise administration of paclitaxel prior to cisplatin... 

The effect of reduced renal function on paclitaxel elimination has not been fully established. However, as renal clearance accounts for only a small proportion of total clearance, dosage modifications are not considered necessary in patients with renal impairment [2 ]. 

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