Paclitaxel cytotoxicities

Huang Y, Ibrado AM, Reed JC, et al. Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells. Leukemia 1997 11(2) 253—257. 

Fjallskog M-L, Frii L, Bergh J. Is cremophor EL, solvent for paclitaxel, cytotoxic Lancet 1993 342 873. 

Folate Paclitaxel Cytotoxicity of paclitaxel-loaded folate-conjugated chitosan nanoparticles was evaluated in vitro [24]... 

Paclitaxel (cytotoxic) by plant cell culture in 75 m bioreactors by Phyton in Germany 1995 Industrial biotransformation prcKess to nicotinamide by Lonza... 

A higher than expected incidence of CHF is also observed in patients treated with DOX and other cytotoxics (e.g., the taxane paclitaxel) or new generation targeted agents (e.g., the humanized anti-ErbB-2/neu monoclonal antibody trastuzumab) [3]. The cardiotoxic synergism of DOX with taxanes or... 

Since the discovery of vesicular structures, termed liposomes, by Alec Bangham, a tremendous amount of work on applications of liposomes has emerged. The use of small unilamellar liposomes as carriers of drugs for therapeutic applications has become one of the major fields in liposome research. The majority of these applications are based on the encapsulation of water-soluble molecules within the trapped volume of the liposomes. Long circulating poly(ethylene glycol) (PEG) modified liposomes with cytotoxic drugs doxorubicin, paclitaxel, vincristine, and lurtotecan are examples of clinically applied chemotherapeutic liposome formulations (1,2). 

Hassan S, et al. Cytotoxic activity of a new paclitaxel formulation, Pacliex, in vitro and in vivo. Cancer Chemother Pharmacol 2005 55 47. 

Q84 Paclitaxel is a cytotoxic antibiotic. Paclitaxel is used in primary ovarian cancer. 

Both omeprazole, a proton pump inhibitor and paclitaxel, a taxane cytotoxic may cause nausea and vomiting as side-effects. Prednisolone, as with other corticosteroids, does not cause nausea and vomiting. Corticosteroids such as dexamethasone are administered to relieve nausea and vomiting, particularly that associated with chemotherapy. 

Paclitaxel is a taxane that was originally derived from the bark of the yew tree. Paclitaxel is used in cytotoxic chemotherapy for malignant disease. 

Evidence has also come to light that suggests that cells containing p53 mutations are more sensitive to paclitaxel s cytotoxic effects than those with wild-type copies of the gene (12-14). Wang et al. outline how thep53 status may impact on paclitaxel sensitivity in their review of paclitaxel induced cell death (15). They suggest that ... 

Trastuzumab (Herceptin) [Antineeplastic/Monoover express the HERlIneu. protein breast CA adjuvant, w/ doxorubicin, cyclophosphamide, and paclitaxel if pt HER2/neu(+) Action MoAb binds human EGF receptor 2 protein HER2) mediates cellular cytotox Dose Per protocol, typical 2 mg/kg/IV/wk Caution [B, ] CV dysfxn, alla-gy/inf Rxns Contra Live vaccines Disp Inj SE Anemia, cardiomyopathy, nephrotic synd, pneumonitis Interactions t Risk of cardiac dysfxn W/ anthracycline, cyclophosphamide, doxorubicin, epirubicin EMS Cardiomyopathy, ventricular dysfxn and pulm tox have been reported monitor for Sxs of reduced cardiac Fxn OD Sxs unknown... 

Miglietta A. et al., Cellular uptake and cytotoxicity of solid lipid nanospheres (SEN) incorporation doxorubicin or paclitaxel, Int. J. Pham., 210, 61, 2000. 

Paclitaxel (Taxol) is a highly complex, organic compound isolated from the bark of the Pacific yew tree. It binds to tubulin dimers and microtubulin filaments, promoting the assembly of filaments and preventing their depolymerization. This increase in the stability of microfilaments results in disruption of mitosis and cytotoxicity and disrupts other normal microtubular functions, such as axonal transport in nerve fibers. 

Taxol (paclitaxel) is a cytotoxic drug that has been shown to have potent antileukemic and tumor inhibitory properties. Taxol suffers from very poor water solubility (0.25 pg/mL), and hence, a few phosphate ester prodrugs of taxol have been synthesized. While great improvement of water solubility was achieved (>10 mg/mL), these prodrugs were resistant to degradation by alkaline phosphatase, probably due to hindered enzyme access, and no free taxol was formed [50],... 

In vitro studies with several tumor cell lines have shown vitamin C to enhance the cytotoxic activity of doxorubicin, cisplatin, paclitaxel, dacarbazine, 5-FU, and bleomycin. Vitamin C has also been shown to increase drug accumulation and to partially reverse vincristine resistance of human nonsmall-cell lung cancer cells. 

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