Three Selected Synthetic Transformations on the Pathway to Paclitaxel

Ojima who suggested the PTX-NY conformer, in which the C-13 side chain is proposed to adopt a different conformation and an alternative hydrogen-bonding pattern in the tubulin binding site [8]. The two conformers were compared to show that only T-Taxol fits the PTX-derived electron crystallographic density [9]. 

All these results underlined the remarkable, nearly perfect fit of the natural product into a naturally unrelated biological target, and directed most of the synthetic efforts towards partial or total synthesis of paclitaxel rather than of its structural congeners. In the following three sections, the specific achievements of the three reactions catalyzed by organometallic complexes are presented, showing the key transformations that provide the key building blocks for paclitaxel. 

3 Three Selected Synthetic Transformations on the Pathway to Paclitaxel 

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