Midecamycin acetate

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... 

C47H7,NOis 55881-06-6) see Midecamycin acetate Ieuco-l,4,S,8-tetrahydroxyanthraquinone (C 4HsOfi 81-60-7) see Mitoxantrone levonorgestrel acetate (C2,H i07 13732-69-9) see Norgestimate levulinic acid... 

Miokamycin (4) is a semi-synthetic derivative of midecamycin A (3), one of the individual factors in the complex produced by Streptomyces mycarofa-ciens [22, 23]. Miokamycin (also spelled miocamycin or called midecamycin acetate, MOM, or ponsinomycin) is 9,3"-di-0-acetylmidecamycin A, Figure 5.2) [24, 25]. 

Sifrim D, Matsuo H, Janssens J, Vantrappen G. Comparison of the effects of midecamycin acetate and azithromycin on gastrointestinal motility in man. Drugs Exp Clin Res 1994 20(3) 121-6. 

Mayama T, Maruyama K, Nakazawa T, lida M. A survey of the side effects of midecamycin acetate (Miocamycin) dry syrup after marketing. Int J Clin Pharmacol Ther Toxicol 1990 28(6) 245-50. 

I., Tomizawa, M., Hiraga, Y, et al. (1989). Double-blind comparative study of roxithromycin (RU 28965) and midecamycin acetate (MOM) in the treatment of pneumonia [in Japanese]. Kansenshogaku Zasshi 63, 501-529. 

A single-dose study in 14 subjects found that after taking midecamycin acetate 800 mg twice daily for 8 days the AUC of a single 200-mg dose of carbamazepine was increased by 15%, and the AUC of its active metabolite (carbamazepine-10,11-epoxide) was reduced by 26%. Another study in patients taking carbamazepine found that the addition of midecamycin acetate 600 mg twice daily caused a small increase in the trough serum levels of earbamazepine, and only an 11.6% increase in the AUC. ... 

Acetylation of tertiary hydroxyl groups. Midecamycin (1), a macrolide antibiotic from S. mycarofacience, is readily converted into the 9,2 -diacetyl derivative by Ac20-Py forcing conditions required for acetylation of the 3"-hydroxyl group result in decomposition. However, reaction of the diacetate with acetyl chloride in ethyl acetate in the presence of a 4 A molecular sieve to scavenge the hydrogen chloride... 

Inoue, S., Omoto, S., Iwamatsu, K., and Niida, T. (1980). Modification of macrolide antibiotic midecamycin. II. Reaction of midecamycin and 9-acetyl midecamycin with dimethylsulfoxide and acetic anhydride. J. Anibiot. 33,61-71. 

The oxidation of midecamycin with dimethyl sulphoxide-acetic anhydride has been studied the macrolide allylic alcohol function was oxidized to the corresponding ketone, whereas the 2 -hydroxy-group on the mycaminose moiety was acetylated rather than oxidized, while the mycarose unit was simultaneously converted to its 3"-0-methylthiomethyl ether derivative. ... 

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