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Paclitaxel dendrimers

Khandare JJ, Jayant S, Singh A, Chandna P, Wang Y, Vorsa N, Minko T. Dendrimer versus linear conjugate Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel. Bioconjugate Chem 2006 17 1464-1472. [Pg.235]

S.T. Lo, S. Stem, J.D. Clogston, J. Zheng, P.P. Adiseshaiah, M. Dobrovolskaia, J. Lim, A.K. Patri, X. Sun, E.E. Simanek, Biological assessment of triazine dendrimer toxicological profiles, solution behavior, biodistribution, drug release and efficacy in a PEGylated, paclitaxel construct. Mol. Pharm. 7 (4) (2010) 993-1006. [Pg.258]

Reactions with dichlorotriazines benefit from markedly enhanced reactivity (over monochlorotriazines) with the amine-terminated dendrimer. Shown in Scheme 10.3, the installation of paclitaxel onto dendrimers is a useful example.Here, the potential of the amine dendrimer to participate in an... [Pg.255]

Scheme 10.3 A reactive dichlorotriazine bearing a paclitaxel group is incorporated into a dendrimer. Worrisome esters are indicated with an arrow. Scheme 10.3 A reactive dichlorotriazine bearing a paclitaxel group is incorporated into a dendrimer. Worrisome esters are indicated with an arrow.
Poly(glycerol)-based dendrimers have been investigated for solubilization of the chemotherapeutic paclitaxel, a complex plant-derived In these studies, H-NMR analyses... [Pg.152]

Effective solubilization of paclitaxel in the presence of polyglycerol dendrimers. Paclitaxel solubility in water is 0.3 pg ml -0.4 Reproduced with permission from Ooya, T. Lee, J. Park, K. Bioconjug. Chem. 2004,15,1221. Copyright 2004 American Chemical Society. [Pg.152]

Dendrimers Synthetic Controlled and sustained drug delivery, bacterial infection, antiviral, vaccine and gene therapy Oncolytic agent Methotrexate,Paclitaxel, Docetaxel, Dithranol... [Pg.246]

Ooya T, Lee J, Park K (2004) Hydrotropic dendrimers of generations 4 and 5 synthesis, characterization, and hydrotropic solubilization of paclitaxel. Bioconjugate Chemistry 15 1221-1229... [Pg.92]

Minko and co-workers linked paclitaxel via succinate linker to PAMAM G4 dendrimers and could show that the drug could be released when the ester bonds were hydrolyzed by esterases. The dendritic carrier was more efficient in cell internalization and showed better cytotoxicity than the free drug and a linear PEG-drug conjugate which proves that dendritic nanocarriers are a highly potent drug delivery platform [82]. [Pg.773]

Lim, J., and Simanek, E. E. 2008. Synthesis of water-soluble dendrimers based on melamine bearing 16 paclitaxel groups. Org Lett 10(2), 201-204. [Pg.1702]

See other pages where Paclitaxel dendrimers is mentioned: [Pg.346]    [Pg.456]    [Pg.2922]    [Pg.2922]    [Pg.143]    [Pg.602]    [Pg.248]    [Pg.419]    [Pg.120]    [Pg.257]    [Pg.260]    [Pg.261]    [Pg.58]    [Pg.100]    [Pg.152]    [Pg.247]    [Pg.247]    [Pg.68]    [Pg.59]    [Pg.614]    [Pg.246]    [Pg.63]    [Pg.37]   
See also in sourсe #XX -- [ Pg.251 , Pg.260 , Pg.262 ]



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