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HPMA copolymer-paclitaxel

A HPMA copolymer-paclitaxel conjugate was tested in phase I clinical studies showing again reduced side toxicity but also only partial remission of skin metastases in breast cancer patient. Also a HPMA copolymer conjugate with campthotecin was... [Pg.48]

HPMA copolymer-paclitaxel (Ester) PNU166945 Pfizer Inc. Phase 1 [109]... [Pg.20]

Figure 3 HPMA copolymer-anticancer conjugates. Panel (a) HPMA copol3mier-doxorubicin (PKl, FCE28068) panel (b) HPMAcopolymer-doxorubicin-galactosamine (PK2, FCE28069) panel (c) HPMAcopoly-mer-paclitaxel panel (d) HPMA copolymer-camptothecin. Figure 3 HPMA copolymer-anticancer conjugates. Panel (a) HPMA copol3mier-doxorubicin (PKl, FCE28068) panel (b) HPMAcopolymer-doxorubicin-galactosamine (PK2, FCE28069) panel (c) HPMAcopoly-mer-paclitaxel panel (d) HPMA copolymer-camptothecin.
Fluoruracil has been linked to HPMA copolymer bearing peptide side-chains via a-glycine (88), and hydrolytically labile terminal ester bonds were used to prepare conjugates of paclitaxel and camptothecin (76,77,116). The endosomal/... [Pg.13]

See other pages where HPMA copolymer-paclitaxel is mentioned: [Pg.98]    [Pg.52]    [Pg.27]    [Pg.28]    [Pg.31]    [Pg.27]    [Pg.28]    [Pg.31]    [Pg.98]    [Pg.52]    [Pg.27]    [Pg.28]    [Pg.31]    [Pg.27]    [Pg.28]    [Pg.31]    [Pg.589]    [Pg.60]    [Pg.124]    [Pg.38]    [Pg.27]    [Pg.230]    [Pg.105]    [Pg.7]    [Pg.27]    [Pg.759]   
See also in sourсe #XX -- [ Pg.27 ]

See also in sourсe #XX -- [ Pg.27 ]



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HPMA copolymer

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