Paclitaxel Paclitaxels

Patient HER2 Levels" Herceptin Paclitaxel Paclitaxel and Herceptin AnthracycUne + Cyclophosphamide Anthracycline + Cyclophosphamide and Herceptin... [Pg.398]

PAMAM G4 Mix of OH, Cy5.5, LHRH targeting peptide, and paclitaxel Paclitaxel Ester Cancer No Yes Yes 320... [Pg.158]

Synthesis of paclitaxel and resiniferatoxin analogs, diterpenoids with oxetane fragments 97G461. [Pg.240]

A higher than expected incidence of CHF is also observed in patients treated with DOX and other cytotoxics (e.g., the taxane paclitaxel) or new generation targeted agents (e.g., the humanized anti-ErbB-2/neu monoclonal antibody trastuzumab) [3]. The cardiotoxic synergism of DOX with taxanes or... [Pg.94]

Taxanes (paclitaxel, docetaxel) are derivatives of yew tree bark (Taxus brevifolia). They stabilize microtubules in the polymerized state leading to nonfunctional microtubular bundles in the cell. Inhibition occurs during G2- and M-phases. Taxanes are also radiosensitizers. Unwanted effects include bone marrow suppression and cumulative neurotoxicity. [Pg.155]

Ranganathan S, Benetatos CA, Colamsso PJ et al (1998) Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells. Br J Cancer 77 562-566... [Pg.417]

Mitotic inhibitors (antimitotics) interfere with or stop cell division. Examples of mitotic inhibitors include paclitaxel (Taxol) and vincristine (Oncovin). [Pg.592]

F.14 Paclitaxel, which is extracted from the Pacific yew tree Taxus brevifolia, has antitumor activity for ovarian and breast cancer. It is sold under the trade name Taxol. On analysis, its mass percentage composition is 66.11% C, 6.02% H, and 1.64% N, with the balance being oxygen. What is the empirical formula of paclitaxel ... [Pg.75]

High pressure cycloaddition of cytraconic anhydride (140) with 2-substituted furans 142 afforded, cxo-diastereoselectively but unregioselectively, bicyclic cycloadducts 143 and 144 that have been used in straightforward routes to CD-ring fragment of paclitaxel [55] (Scheme 5.22). The cycloadducts were then... [Pg.231]

C2H3BrO 506-96-7) see Paclitaxel N-acetyl-2 -bromo-2 -deoxycytidine 3, S -diacetate (C 5HigBrN307 126430-12-4) see Zalcitabine A -acetyl-3 -bromo-3 -deoxycytidine 2, 5 -diacetate (C 5H gBrN307 126430-11-3) see Zalcitabine 2-acetyl-4-butyramidophenol (C 2H,5N03 40188-45-2) see Acebutolol... [Pg.2283]

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... [Pg.2283]

C7H )N2 1122-58-3) see Paclitaxel Zafiilukast 4-dimethylamino-3-(4-pyridyl)-3-bulen-2-one (CHH14N2O 7 504 61-7) see Milrinone 2-dimethylaminosulfunylphenothiazine... [Pg.2362]

ChH, N20 1659-31-0) see Paclitaxel l-(2 (i-dipyrrolidino-4-pyrimidinyl)pipera7jne (C f,H2(iN(5 111641-17-9) see Tirilazad mesilate S)-l, 4-dithia-7-azaspiro[4.4)nonane-S carboxylic acid hydrobromide... [Pg.2370]

C4H,0, 623-50-7) see Paclitaxel 13-ethylgona-5(10),15-diene-3,17-dione cyclic 3-(2,2-di-methyl-l,3-propanediyl acetal)... [Pg.2380]

C5H9NO 10431-98-8) see Nefazodone hydrochloride ( )-ethyl 2-oxo-3-benzoylamino-3-phenylpropionate (C H,7N04 153433-79-5) see Paclitaxel ethyl 3-oxocaproatc... [Pg.2383]

C20H2JNO3 3608-67-/) see Propiverine (-)-(lS,2S)-/V-(2-hydroxy-l-phenyl-3-butenyl)benzamide (C17H17NO2 136693-02-2) see Paclitaxel [hydroxy(4-phenylbutyl)phosphinyl]acetic acid phenylmc-thyl ester... [Pg.2399]

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