Anticancer paclitaxel

Poly(ADP-ribose)polyrmerase (PARP) inhibitors, 42 (2004) 125 P2 Purinoreceptor ligands, 38 (2001) 115 p38 MAP kinase inhibitors, 38 (2001) 1 Paclitaxel, anticancer agent, 32 (1995) 289... 

Merum Terwogt JM, Ten Bokkel Huinink WW, Shellens JH, et al. Phase I clinical and pharmacokinetic study of PNU 166945, a novel polymer-conjugated prodrag of paclitaxel. Anticancer Drags 2001 12 315-323. 

Paclitaxel Anticancer Vitamin E TPGS, Ethanol, Deoxycholate, Vitamin E, Cremophore RH 40, PG Increased BA as compared to oral Taxol [94]... 

Skubitz, K. M., A phase I study of ambulatory continuous infusion paclitaxel. Anticancer Drugs, 8(9), 823, 1997. 

Paclitaxel (anticancer), tetracycline hydrochloride Tetracycline hydrochloride Centdia asiaft ca-herbal Extract... 

Triazine Paclitaxel Anticancer drug delivery system PEG chains Lim and Simanek (2008)... 

The significance of P-gp, however, in affecting absorption and bioavailability of P-gp substrate drugs can be seen in studies in knockout mice that do not have intestinal P-gp. The gene responsible for producing that protein has been knocked out of the genetic repertoire. Those animals evidenced a sixfold increase in plasma concentrations (and AUC, area under the plasma concentration-time curve) of the anticancer drug paclitaxel (Taxol) compared to the control animals [54]. Another line of evidence is the recent report... 

There are natural targets whose syntheses have important practical applications. For example, paclitaxel (marketed as Taxol by Bristol-Myers Squibb) is an anticancer compound originally isolated from the bark of a species of yew tree, but for a long time it seemed that natural sources would not be sufficient to meet the need. Consequently, many chemists developed synthetic approaches to paclitaxel from readily available materials, although these are not yet fully practical for manufacturing. The quest continues, and a semisynthetic route has been developed starting with a compound isolated from yew needles that can be harvested without destroying the tree. An alternative approach has employed plantcell cultures in bioreactors to produce paclitaxel from yew needles (see Chapter 7 for discussion of related matters). 

Other applications include bioequivalent measurements of bromazepam, an anticonvulsant, in human plasma. The lower limit of quantitation (LLOQ) was 1 ng/mL (Gongalves et al. 2005). Kuhlenbeck et al. (2005) studied antitussive agents (dextromethorphan, dextrophan, and guaifenesin) in human plasma LLOQ values were 0.05, 0.05, and 5 ng/mL, respectively. Other compounds studied were nucleoside reverse transcriptase inhibitors, zidovudine (AZT) and lamivudine (3TC) (de Cassia et al. 2004) and stavudine (Raices et al. 2003) in human plasma, and paclitaxel, an anticancer agent, in human serum (Schellen et al. 2000). 

A paclitaxel fullerene derivative has been obtained by covalent linkage of the dmg to the C60 by means of an ester, the hydrolysis of which presents a favorable kinetic profile, with consequent release of paclitaxel (Zakharian et al., 2005). The in vitro tests show a good anticancer activity, holding out hope for enhancing the dmg efficacy... 

A. Gadducci, S. Cosio, A. Fanucchi, V. Nardini, M. Roncella, P.F. Conte, and A.R. Genazzani. Chemotherapy with epirubicin and paclitaxel for breast cancer during pregnancy Case report and review of the literature. Anticancer Res. 23 5225-5229 (2003). 

Anticancer drugs Paclitaxel Docetaxel Vinblastine Vincristine Tipifarnib Diflomotecan Iiinotecan Doxorubicin Daunorubicin Etoposide Tenoposide Tamoxifen (i)... 

Anticancer drugs Methotrexate Doxorubicin Daunorubicin Epirubicin Etoposide Vincristine Vinblastine Paclitaxel Iiinotecan... 

Other anticancer agents have distinct mechanisms paclitaxel and its relatives target microtubules as do the vinca alkaloids. Antiestrogens and antiandrogens target estrogen and androgen receptors. 

Paclitaxel (21) Taxus hrevifolia Nutt, (western or pacific yew) Anticancer... 

Paclitaxel (21), formerly known as taxol , is a nitrogen-containing diterpenoid compound isolated from the bark of Taxus brevifolia Nutt. (Pacific yew). As an anticancer agent, paclitaxel acts as a tubulin stabilizer and leads to cell cycle arrest.Since paclitaxel was originally isolated from the bark of the slow-growing species, 77 brevifolia, sourcing was a major obstacle in the development of this drug and its introduction into the market.However, as described later in this chapter, this has now been overcome. 

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