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Paclitaxel conjugates

Li, C. Yu, D.-R Newman, R. A. Cabral, P. Stephens, L. C. Milas, L. Wallace, S. Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res., 1998, 58 2404—2409. [Pg.138]

Dosio, R Arpicco, S. Brusa, R Stella, B. Cattel, L. Roly(ethylene glycol)-human serum albumin-paclitaxel conjugates preparation, characterization and pharmacokinetics. J. Controlled Release, 2001 76 107-117. [Pg.138]

Being the first poly(glutamic acid) conjugate tested in clinical trials, paclitaxel conjugate of poly(glutamic acid) (CT-2103) was observed to have superior antitumor activity to free paclitaxel. In preclinical studies, it was evidenced that the whole conjugate extravasated to the tumor site and the drug was released extracellularly in... [Pg.1331]

Figure 2 Structure of paclitaxel conjugated via an acyl hydrazide bond to the Hyaluronan... Figure 2 Structure of paclitaxel conjugated via an acyl hydrazide bond to the Hyaluronan...
OPAXIO, Poly(L-Glutantic Acid)-Paclitaxel Conjugates... [Pg.110]

E. Oldham, C. Li, S. Ke, S. Wallace, P. Huang, Comparison of action of paclitaxel and poly (L-glutamic acid)-paclitaxel conjugate in human breast cancer cells, Int. J. Oncol. 16 (2000) 125—132. [Pg.64]

Li C, Yu D, Inoue T, Yang DJ, Milas L, Hunter NR, Kim EE, Wallace S (1996) Synthesis and Evaluation of Water-Soluble Polyethylene Glycol-Paclitaxel Conjugate as a Paclitaxel Prodrug. Anti-Cancer Drugs 7 642... [Pg.214]

A HPMA copolymer-paclitaxel conjugate was tested in phase I clinical studies showing again reduced side toxicity but also only partial remission of skin metastases in breast cancer patient. Also a HPMA copolymer conjugate with campthotecin was... [Pg.48]

C. Chamsangavej, and S. Wallace. 2000. Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumour. Cancer Chemother.Pharmacol. 46 416-422. [Pg.97]

Singer, J. W., de Vries, P., Kumar, A., Baker, B., Lyim, S., Li, C., and Wallace, S. Poly-L-Glutamic Acid Paclitaxel Conjugate (PG-TXL) A water-soluble biodegradable conjugate with decreased toxicity and enhanced efficacy. 4th International Symposium on Polymer Therapeutics. 2000. [Pg.98]

D., Main, M., Brannan, M. D., Elliott, S., Verrill, M., and Calvert, H. Phase 1 and pharmacological study of CT-2103, a poly(L-glutamic acid)-paclitaxel conjugate. [Pg.99]

See other pages where Paclitaxel conjugates is mentioned: [Pg.369]    [Pg.163]    [Pg.73]    [Pg.105]    [Pg.120]    [Pg.18]    [Pg.217]    [Pg.219]    [Pg.122]    [Pg.97]    [Pg.33]    [Pg.115]    [Pg.86]    [Pg.99]    [Pg.97]    [Pg.33]    [Pg.115]    [Pg.56]    [Pg.157]    [Pg.153]    [Pg.52]   
See also in sourсe #XX -- [ Pg.5 , Pg.258 ]



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