Paclitaxel brain tumors

Glantz MJ, Chamberlain MC, Chang SM, Prados MD, Cole BF. The role of paclitaxel in the treatment of primary and metastatic brain tumors. Semin Radiat Oncol 1999 9(2 Suppl l) 27-33. 

Glantz MJ, Choy H, Kearns CM, Akerley W, Egorin MJ. Weekly, outpatient paclitaxel and concurrent cranial irradiation in adults with brain tumors preliminary results and promising directions. Semin Oncol 1995 22(5 Suppl 12) 26-32. 

Glantz MJ, Choy H, Kearns CM, et al. Paclitaxel disposition in plasma and central nervous systems of humans and rats with brain tumors. J Natl Cancer Inst 1995 87(14) 1077-1081. 

Fetell MR, Grossman SA, Fisher JD, Erlanger B, Rowinsl E, Stockel J, Piantadosi S. Preirradiation paclitaxel in glioblastoma multiforme efficacy, phaimacolc, and drug interactions. New approaches to Brain Tumor Therapy Central Nervous System Consortium. J Clin 0 <7o/(1997) 15, 3121-8. 

Torres, A.J., Zhu, C., Shuler, M.L., Pannullo, S. Paclitaxel delivery to brain tumors from hydrogels a computational study. Biotechnol. lAog. 27(5), 1478-1487 (2011). 

Concurrent therapy for the treatment of more than three brain metastases using paclitaxel and radiation has been explored in a phase III trial (144). The hypothesis here being that high-dose paclitaxel in combination with cranial radiation should improve local control while providing systemically active amounts of chemotherapy. Unfortunately, there was no statically significant improvement in survival seen. There is certainly a place to further explore the benefits and toxicides experienced with concurrent taxane-based therapy with radiation in metastatic disease. The role of the taxanes in concurrent chemoradiotherapy with sarcomas and pediatric tumors has not been explored at this time. 

The pilot study in normal volunteers and breast cancer patients with [iSpjFPAC was approved by the Virginia Commonwealth University Institutional Review Board, who developed an automated method for F-fluorination of paclitaxel [133]. The biodistribution of [ FjFPAC in normal volunteers was similar to that observed in the previous study in primates with lower background activity in chest, breast, and brain. The extensive hepatic clearance and subsequent excretion into the bowel can compromise the diagnostic value of [iSpjFPAC imaging in abdominal tumors. 

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