Myalgia paclitaxel

Paclitaxel -natural taxane inhibits depolymerization of tubulin in mitotic spindle apparatus -bone marrow suppression -nausea and vomiting—mild -mucocutaneous effects (mucositis, stomatitis, diarrhea) -hypersensitivity reactions -peripheral neuropathy -myalgias, arthralgias -mild vesicant... 

Hypersensitivity reactions can occur due to the presence of contaminants or excipients in pharmaceutical dosage forms (e.g., outbreaks of eosinophilia-myalgia syndrome associated with oral tryptophan contaminants in various drugs). Another example is the anaphylactoid reactions to the surfactant Cremaophor EL, which is used in paclitaxel (Taxol). 

The severity of myalgia and arthralgia correlated significantly with the total cumulative dose of paclitaxel 210 mg/m /cycle by 3-hour infusion in 247 patients with a median cumulative dose of 630 mg/m (47). 

Bone or joint pain (7%) Myalgia/Myositis/Myopathy/Myotoxicity ( I %) (2003) Leyland-Jones B+,) Clin Oncol 21(21), 3965 (with paclitaxel)... 

Neurotoxicity may be severe enough to require discontinuation treat myalgias/arthralgias with NSAIDs, narcotic analgesics In paclitaxel-cisplatin combination regimens, give paclitaxel first to decrease neutropenia... 

Musculoskeletal Arthralgia and/or myalgia have been reported in 20-30% of patients receiving paclitaxel they typically occur... 

Musculoskeletal Docetaxel is associated with arthralgias and myalgias, usually starting 1-2 days after infusion and lasting up to 5 days [142 ]. As with paclitaxel, gaba-pentin given prophylactically controls symptoms in some patients [69 ]. 

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