Poly paclitaxel incorporation into

The effect ofthe medium composition orthe loaded drug on the CMC may be difLcuitto predict. Zhang, Jackson, and Burt (1996a) found that the incorporation of 10% paclitaxel into MePEO-b PDLLA micelles did not cause the CMC to change signiLcantly. Those authors also showed that the CMC of methoxy (Me) PECb-PDLLA (poly(DL-lactic acid)) micelles remained the same in water,... 

Polymeric micelles, which were first introduced by Ringsdorf in 1984 [14], are an assembly of amphiphilic block copolymers in an aqueous environment. Primary polymeric micelles have a well-defined core-shell structure - a hydrophobic inner core and a hydrophilic shell. Micelles can incorporate water-insoluble drugs into the cores through chemical, physical, or electrostatic interactions [15], such as in micelles that are composed of a block copolymer of poly(ethylene glycol) and polyaspartate (Fig. 2) [16-18], A phase II study of a paclitaxel (PTX)-incorporated micelle, NK105, that is used in the treatment of stomach cancer, has begun [19]. 

Several anti-cancer drugs can be incorporated in polymer nanofibers for subsequent sustained release into the surrounding microenvironment. To date, paclitaxel is the agent most widely investigated in this framework. " Doxorubicin has also been studied as a model for encapsulation within biodegradable nanofibers of poly(ethylene glycol)-PLA copolymers. " ... 

---