Targeting agents

A higher than expected incidence of CHF is also observed in patients treated with DOX and other cytotoxics (e.g., the taxane paclitaxel) or new generation targeted agents (e.g., the humanized anti-ErbB-2/neu monoclonal antibody trastuzumab) [3]. The cardiotoxic synergism of DOX with taxanes or... 

In this part we shall examine the potential of NT receptors-targeting agents as therapeutic drugs. 

As was noted previously, the CBMS II is required to detect and identify both CWA and BWA in three different monitoring modes. The list of CWA target agents is not available for public release, but it includes the common nerve,... 

This requirement is important to ensuring that the CBMS II alarms for the correct agent. The requirement is for the CBMS II to produce substantially fewer false positive and false negative alarms and misidentilications than the current CWA and BWA detectors. The design of the CBMS II incorporates several features that improve selectivity over that of previous detectors. These include Cl and MS/MS, and for some target agents, MS/MS/MS. 

In most other cases, the lysosomes are a transit compartment en route to the cytoplasm. In case the targeted agent is lysosomally unstable (e.g. DNA) this compartment should be avoided. 

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