Paclitaxel extravasation

Hyaluronidase is the antidote of choice for vinca alkaloid and high-concentration epipodophyllotoxin extravasations. Hyaluronidase breaks down hyaluronic acid, which functions as tissue cement. This promotes absorption of the extravasated drug away from the local site. Hyaluronidase also may be used for paclitaxel extravasations, but there are conflicting reports regarding its efficacy.39 Hyaluronidase should not be used with anthracycline extravasations because enhancement of local spread may occur. 

Being the first poly(glutamic acid) conjugate tested in clinical trials, paclitaxel conjugate of poly(glutamic acid) (CT-2103) was observed to have superior antitumor activity to free paclitaxel. In preclinical studies, it was evidenced that the whole conjugate extravasated to the tumor site and the drug was released extracellularly in... 

Local venous effects, including erythema, tenderness, and discomfort, can occur at the injection site during paclitaxel infusion (13). Inflammation is evident within hours and usually resolves within 21 days. Inflammation occurs in areas of drug extravasation along with prolonged soft tissue injuries, and necrotic changes have been reported in one patient at the site of extravasation (41). Inflammation is most likely to be due to the drug, but the Cremophor EL vehicle may be implicated, as it produces mild inflammation in animals (41). 

There is little information on the treatment of extravasation of paclitaxel, as it has not been common during clinical trials. However, a soft-tissue injury occurred in one patient at the site of previous extravasation after treatment with paclitaxel in a different Umb (42). This resolved within 7 days. 

There is little information on the treatment of extravasation of paclitaxel, as it has not been common during clinical trials. 

Shapiro J, Richardson GE. Paclitaxel-induced recall soft tissue injury occurring at the site of previous extravasation with subsequent intravenous treatment in a different hmb. J Clin Oncol 1994 12 (10) 2237-8. 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ ]

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