Benfurodil hemisuccinate

To a solution of 24.7 parts of 1 -(m-trifluoromethylphenyl)-2-(/3-hydrOxyethyl)amino propane in 140 parts Of anhydrous benzene, there were added successively 15 parts of 4.7 N hydrochloric ether and a solution of 14 parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition required 10 minutes, the reaction mixture was then refluxed for 8 hours. 

The solid product was collected by filtration and after recrystallization from 230 parts of ethyl acetate, there were obtained 15 parts of 1-(m-trifluoromethylphenyl)-2-( enzoyloxy-ethyDamino propane hydrochloride melting at 161°C. 

10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts ether are added, then 10 parts of a concentrated solution of ammonium hydroxide. The mixture is stirred a few minutes until the salt is dissolved, then theethered solution is poured off and dried. After the ether is eliminated, 9 parts of 1-(m-trifiuoromethylphenyl)-2-( enzoyloxyethyl)amino propane are obtained the base is a colorless oil. 

Beregl, L. Hugon.P. and Le Douarec, J.C. U.S.Patent 3,607,909 September 21,1971 assigned to Science Union et Cie Societe Prancaise de Recherche Medicale 

Chemical Name succinic acid monoester with 4-[2-(1-hydroxyethyl)-3-methyl-5-benzo-furanyl] -2(5H)-furanone 

1 (m-Trifluoromethvlphenvl)-2-(j3-hvdroxvethyl)amino Propane Benzoyl Chloride 

1 -(m-Trifluoromethylphenyl)-2-( 3-hydroxyethyl)amino Propane Benzoyl Chloride 

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Benfurodil hemisuccinate Benzbromarone Mexiletine HCI Chloroacetonitrile Bendazac... 

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... 

C3H3CIO 78-95-5) see Befunolol Benfurodil hemisuccinate Benzarone Mexiletine Ofloxacin Secnidazole Sertaconazole Zoraepirac chloroacetonitrile... 

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