Hydrocortisone 21-cypionate

Corticosteroids and esters (hydrocortisone, hydrocortisone 17-butyrate, hydrocortisone 21-acetate, hydrocortisone 17-valerate, hydrocortisone 21-caprylate, hydrocortisone 21-cypionate, hydrocortisone 21-hemisuccinate)... 

Figure 8.7. Graph of injection number versus retention time of hydrocortisone, hydrocortisone 21-hemisucdnate, hydrocortisone 21-cypionate and its impurity using a run buffer composed of 50-mM hydroxypropyl-P-cyclodextrin added to the 100-mM SDS, 25-mM sodium tetraborate run buffer. All the samples were detected using UV at 254 nm.

Figure 8. Electropherograms of (.A) 1st injection and (B) 60th injection of the (1) hydrocortisone 21-hemisuccinate, (2) hydrocortisone, (3) hydrocortisone 21-cypionate, and (4) impurity using a 27 cm X 50pm open tube capillary with 10-mM sodium tetraborate, 100-mM SDS, and 50-mM hydroxypropyl-p-cyclodextrin.

Parenteral 25, 50 mg/mL suspension for intralesional, soft tissue, or intra-articular injection Hydrocortisone cypionate (Cortef)... 

J. W. Munson and T. D. Wilson, High-performance liquid chromatographic determination of hydrocortisone cypionate Method development and characterization of chromatographic behavior, J. Pharm. Sci., 70 11 (1981). 

Cortisone (25 to 300 mg/day) is insoluble in water. Cortisone acetate (Biofine) is available in a 25-mg tablet. Hydrocortisone (cortisol, 20 to 240 mg/day) exists in suspension and is insoluble in water. Hydrocortisone cypionate (Cortef, 20 to 240 mg/day) is available in an oral suspension. Hydrocortisone sodium phosphate, a water-soluble salt with a rapid onset but short duration of action, is available for IV, IM, or SC injection. Hydrocortisone sodium succinate (Solu-Cortef) in an initial dose of 100 to 500 mg may be administered IV or IM. The antiinflammatory effect of corfisol is relatively weak (Table 11). 

Hydrocortisone and hydrocortisone cypionate (Cortef) may be administered orally. Hydrocortisone sodium phosphate may be administered by IM, SC, or IV injection, or by IV infusion, q. 12-hour interval. Hydrocortisone sodium succinate (A-hydroCort, Lifocort, Solu-Cortef) may be administered by IM or rV injection or IV infusion q. 2 to 10 hours, depending on the clinical situation. Hydrocortisone acetate is a suspension that may be administered by intra-articular, intrasynovial, intrabursal, intralesional, or soft tissue injection. It has a slow onset but a long duration of action. The injectable forms are usually used only when the oral dosage forms cannot be used (see also Table 11). 

Other ester derivatives that are available include hydrocortisone cypionate [21-(3-cyclopentylpropionate) ester], hydrocortisone butyrate (1 7a-butyrate ester), hydrocortisone buteprate (17a-butyrate, 21-propionate esters), hydrocortisone valerate (17a-valerate ester), hydrocortisone sodium succinate (21-sodium succinate ester), and hydrocortisone sodium phosphate (the 21-sodium phosphate ester) (Fig. 33.10). The water-insoluble hydrocortisone cypionate is used orally in doses expressed in terms of hydrocortisone for slower absorption from the gastrointestinal (Gl) tract. The extremely water-soluble 21-sodium succinate and 21-sodium phosphate esters are used for IV or IM injection in the management of emergency conditions that can be treated with anti-inflammatory steroids. The phosphate ester is completely ... 

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