Hydrocortisone 21-acetate

I60C-Hydroxy Derivatives of Gorticoids and their Acetonides. The preparation of 16a-hydroxy-9a-fluoroprednisolone (48) from the 3,20-bisethylene ketal of hydrocortisone acetate (49) has been reported (73). The latter was dehydrated with thionyl chloride in pyridine to yield the 4,9(11),16-triene (50). The 16,17-unsaturated linkage was selectively hydroxylated with OsO /pyridine to yield the 16a,17a-diol (51), which was converted... 

Crystallization and Purification Solvent. Dimethylacetamide is useful ia the purification by crystallization of aromatic dicarboxyHc acids such as terephthahc acid [100-21-0] and/vcarboxyphenylacetic acid [501-89-3]. These acids are not soluble ia the more common solvents. DMAC and dibasic acids form crystalline complexes containing two moles of the solvent for each mole of acid (16). Microcrystalline hydrocortisone acetate [50-03-3] having low settling rate is prepared by crystallization from an aqueous DMAC solution (17). 

The combined pharmaceutical appHcations account for an estimated 25% of DMF consumption. In the pharmaceutical industry, DMF is used in many processes as a reaction and crystallizing solvent because of its remarkable solvent properties. For example, hydrocortisone acetate [50-03-3] dihydrostreptomycin sulfate [5490-27-7] and amphotericin A [1405-32-9] are pharmaceutical products whose crystallization is faciHtated by the use of DMF. Itis also a good solvent for the fungicide griseofulvin/72%(97-< 7 and is used in its production. 

J, C2 H2qO, or hydrocortisone acetate [50-03-3] 6 analgesic diperidon [537-12-2] C22H2gCLN204, or a detergent, eg, thon2onium... 

One of the first indications that the antiinflammatory potency of the corticoids could be increased was the observation that incorporation of a 9a-fluoro group in hydrocortisone resulted in a tenfold increase in activity. Treatment of hydrocortisone acetate (170a) with phosphorus oxychloride in pyridine yields the corresponding olefin, 172. This, on being subjected to the reaction sequence depicted in the transformation of 104 to 108 (addition of HOBr, closure to the epoxide and ring opening with HF),... 

Fluprednisolone Acetate Hydrocortisone Acetate Methylprednisolone Methylprednisone 163-MethyIpredni sone Prednylidene Triamcinolone Triamcinolone Acetonide... 

Hydrochlorothiazide U 358 Hydrocodone 1, 288 Hydrocortisone U 190 Hydrocortisone acetate 1, 190 Hydroflumethiazide 3 5 8... 

Hydrocortisone acetate is first reacted with phosphorus oxychloride in pyridine to give the... 

Corticosteroid intrarectal foam, hydrocortisone acetate intrarectal foam Cortifoam Adjunctive therapy in treatment of ulcerative proctitis of the distal portion of the rectum Local pain or burning, rectal bleeding, apparent exacerbations or sensitivity reactions 1 applicatorful once or twice daily for 2 wk and every second day thereafter... 

C2 H3()05 50-23-7) see Bcndacort Cloprednol Desonide Hydrocortisone acetate Hydrocortisone 17-butyrate Hydrocortisone sodium phosphate Methylprednisolone Prednisolone... 

Irreversible reaction of [18] iodine with acetylsalicylic acid, aethaverine, amidopyrine, ascorbic acid, benzo-caine, quinine, dihydrocodeine, fluorescein, glycine, hydrocortisone acetate, isoni-azid, metamizole, papaverine, paracetamol, phenacetin, phenol-phthalein, piperazine, resorcinol, salicylic acid, salicylamide, sulfaguanidine, thymol, triethanolamine, tris buffer detection by reaction chromatography... 

Hydrocortisone microspheres (108,109) and films (110) based on poly(lactic acid) have been investigated. A cage implant technique was used to study the performance of monolithic poly (DL-lactide) films loaded with hydrocortisone acetate (110). Films 1.5 x 0.6 cm were inserted into titanium wire-mesh cages 3.5 x 1.0 cm. The cages were implanted in the backs of rats and the inflammatory exudate was sampled periodically. The white cell concentration in the samples was lower than that of controls at all times during the 21-day test. 

Hydrocortisone acetate Cream, lotion, ointment All strengths Low VII... 

Oxytetracycline preparations for oral administration should contain not less than 90% or not more than 120% [i] or not less than 90% and not more than 110% [2], of the labeled amount. For ointment, the requirements are not less than 90.0% and not more than 115% (for oxytetracycline HC1 and Hydrocortisone ointment, or 120% for other ointment. For ophthalmic suspension mixture with hydrocortisone acetate, its content should contain not less than 90% and not more than 110% [1]. 

How many grams of 2% ophthalmic hydrocortisone acetate ointment and how many grams of ophthalmic base (diluent) should be used in compounding the prescription ... 

What would be the displacement value of hydrocortisone acetate if it is known that ten suppositories containing 250 mg each of the drug weigh 20.83 g ... 

However, it is pertinent to mention here that certain steroids esterified at C-21 position, such as hydrocortisone acetate, methylprednisolone acetate are duly hydrolyzed in the alkaline medium to give rise to the corresponding free C-21 hydroxy steroids and hence, may also be assayed by adopting the same procedure. 

Theory Hydrocortisone acetate is first hydrolysed by strong trimethylammonium hydroxide solution to yield the free 21-hydroxysteroid i.e., hydrocortisone as shown below ... 

Materials Required Hydrocortisone acetate 0.350 g aldehyde-free absolute ethanol 100 ml triphenyltetrazolium chloride solution [a 0.5% w/v solution of 2,3,5, -triphenyltetrazolium chloride in aldehyde-free ethanol (96%)] 10 ml dilute tetramethylammonium hydroxide solution [Dilute 10 ml of tetramethylammonium hydroxide solution (10%) to 100 ml with aldehyde-free ethanol (96%). It contains about 1% w/v of C4H13NO. To be prepared immediately before use] 10 ml. 

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