Maintenance dosage

If patient is hemodynamically stable, reduce dosage to 25 mg every 6 hours for 24 hours and then taper to maintenance dosage over 3-5 days. 

Initial dose 100 mg qd, increase by 100-mg increments/vi k until uric acid levels <6.5 mg/dL max 800 mg/d. Usual maintenance dosage 300 mg/d reduce in renal insufficiency rash, Gl intolerance common. Marrow suppression, hepatitis. 

Special populations - In elderly, debilitated, or malnourished patients, or patients with renal, hepatic, or adrenal insufficiency, the initial dosing, dose increments, and maintenance dosage of rosiglitazone/glimepiride should be conservative to avoid hypoglycemic reactions. 

Maintenance dosage Most patients require 1 tablet Thyrolar 1 to 1 tablet Thyrolar 2 per day failure to respond to 1 tablet Tf7yro/ar 3 suggests lack of compliance or malabsorption. 

Increase the daily dose only when the clinical response is not adeguate or the concentration of free serum copper is persistently above 20 mcg/dL. Determine optimal long-term maintenance dosage at 6- to 12-month intervals. 

Digoxin injection is frequently used to achieve rapid digitalization, with conversion to digoxin tablets or capsules for maintenance therapy. If patients are switched from IV to oral digoxin formulations, make allowances for differences in bioavailability when calculating maintenance dosages (see Pharmacology). 

Usual Digitalizing and Maintenance Dosages for Digoxin Capsules in Children with Normal Renal Function Based on Lean Body Weight ... 

Reduce loading (bolus) doses - Reduce loading (bolus) doses in patients with congestive heart failure (CHF) or reduced cardiac output and in the elderly. However, some investigators recommend the usual loading dose be administered and only the maintenance dosage be reduced. 

Initiate therapy with 20 mg orally once daily, then increase by 10 mg/week, or longer intervals, to attain adequate control of blood pressure. The usual maintenance dosage is 20 to 40 mg once daily. BP response increases over the 10 to 60 mg/day dose range, but adverse event rates also increase. Doses more than 60 mg once daily are not recommended. 

As the desired heart rate or endpoint is approached, the loading infusion may be omitted and the maintenance infusion titrated to 300 mcg/kg/min (0.3 mg/kg/min) or downward as appropriate. Maintenance dosages more than 200 mcg/kg/min (0.2 mg/kg/min) have not been shown to have significantly increased benefits. The interval between titration steps may be increased. ... 

If adequate therapeutic effect is not observed within 5 minutes, repeat loading dose and follow with maintenance infusion increased to 100 mcg/kg/min. Continue titration procedure, repeating loading infusion, increasing maintenance infusion by increments of 50 mcg/kg/min (for 4 minutes). As desired heart rate or a safety endpoint (eg, lowered blood pressure) is approached, omit loading infusion and titrate the maintenance dosage up or down to endpoint. Also, if desired, increase interval between titration steps from 5 to 10 minutes. 

Maintenance dosage - 100 to 450 mg/day. Dosages greater than 450 mg/day have not been studied. While once daily dosing is effective and can maintain a reduction in blood pressure throughout the day, lower doses (especially 100 mg) may not maintain a full effect at the end of the 24-hour period larger or more frequent daily doses may be required. 

In patients who tolerate the full IV dose (15 mg), give 50 mg orally every 6 hours 15 minutes after the last IV dose and continue for 48 hours. Thereafter, administer a maintenance dosage of 100 mg twice daily. 

Maintenance dosage Usual dose is 40 to 80 mg once daily. Up to 160 to 240 mg once daily may be needed. The safety and efficacy of dosages exceeding 240 mg/day have not been established. 

Maintenance dosage 20 to 40 mg/day. Titrate, depending on blood pressure and heart rate. Increases to a maximum of 60 mg/day divided into 2 doses may be necessary. There should be an interval of at least 7 days between dosage increases. 

Maintenance dosage - 20 to 40 mg/day as a single dose or 2 divided doses. A dose of 80 mg gives an increased response, but experience is limited. Total daily doses above 80 mg have not been evaluated. If blood pressure is not controlled with benazepril alone, add a diuretic. 

Maintenance dosage - Usual range needed to maintain a response is 20 to 40 mg/day but some patients appear to have a further response to 80 mg. If trough response is inadequate, consider dividing the daily dose. 

Maintenance dosage 10 mg once daily. If the patient is hypertensive or recently post-MI, it can also be given as a divided dose. 

Maintenance dosage 2.5 to 20 mg/day as a single dose or in two equally divided doses. If BP is not controlled with ramipril alone, a diuretic can be added. 

Maintenance dosage Titrate to greatest tolerated dose. 

Children Initial dose is 25 mg. Make careful increments of 25 mg to achieve maintenance. Dosage for infants has not been established. 

Maintenance therapy- Continue the dosage that maintains normal serum uric acid levels. When there have been no acute attacks for 6 months or more and serum uric acid levels have remained within normal limits, decrease the daily dosage by 0.5 g every 6 months. Do not reduce the maintenance dosage to the point where serum uric acid levels increase. 

Adult maintenance dosage - The usual maintenance dose is 75 to 150 mg/day. 

Maintenance - Dosage may be reduced to 75 to 150 mg/day with adjustment depending on therapeutic response. 

Maintenance dosage - After maximum clinical response is achieved, attempt to reduce the dosage slowly over a period of several weeks without jeopardizing therapeutic response. Beneficial effect may not be seen in some patients for 3 to 6 weeks. If no response is obtained by then, discontinue therapy. 

Maintenance dosage Individualize with titration upward or downward based on therapeutic response. 

Initially, 1 g of phenytoin capsules is divided into 3 doses (400 mg, 300 mg, 300 mg) and administered at intervals of 2 hours. Normal maintenance dosage is then instituted 24 hours after the loading dose, with frequent serum level determinations. 

Adults Initial dose should not exceed 1.5 mg/day in 3 divided doses. Increase in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Individualize maintenance dosage. Maximum recommended dosage is 20 mg/day. 

Reduce dosage Reduce dosage as soon as initial control of symptoms is achieved. Maintenance dosage may be as low as % of the initial daily dosage. Do not exceed recommended dosage. Clinical improvement of acute diarrhea is usually observed within 48 hours. If clinical improvement of chronic diarrhea is not seen within 10 days after a maximum daily dose of 20 mg, symptoms are unlikely to be controlled by further use. 

Ulcerative colitis Inform patients with this condition that ulcerative colitis rarely remits completely, and that the risk of relapse can be substantially reduced by continued administration of sulfasalazine at a maintenance dosage. Glucose-6-phosphate dehydrogenase deficiency Observe patients with glucose-6-phosphate dehydrogenase deficiency closely for signs of hemolytic anemia. This reaction is frequently dose-related. 

Hepatic function impairment In patients with severe hepatic impairment (Child-Pugh class C), the initial dose of tigecycline should be 100 mg followed by a reduced maintenance dosage of 25 mg every 12 hours. Treat patients with severe hepatic impairment with caution and monitor them for treatment response. 

Dosage adjustment- If patients are unable to tolerate 4 mg/kg IV, reduce the IV maintenance dosage to 3 mg/kg every 12 hours. 

Coadministration with phenytoin Phenytoin may be coadministered with voriconazole if the IV maintenance dosage of voriconazole is increased to 5 mg/kg every 12 hours. 

To prevent uric acid nephropathy during chemotherapy PO Initially, 600-800 mg/day starting 2-3 days before initiation of chemotherapy or radiation therapy. IV 200-400 mg/mVday beginning 24-48 hr before initiation of chemotherapy. Akrt Maintenance dosage is laased on serum uric acid levels. Discontinue following the period of tumor... 

Adjunctive treatment of Lennox-Castaut syndrome (petit mal variant) and akinetic, myoclonic, and absence (petit mal) seizures PO 1.5 mg/day may be increased in 0.5-to 1-mg increments every 3 days until seizures are controlled. Don t exceed maintenance dosage of 20 mg/day. 

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