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Pheniramine maleate

A solution containing 741 g (5.0 mols) of 1-phenyl-2-propylidenylhydrazine, 300 g (5.0 mols) of glacial acetic acid and 900 cc of absolute ethanol was subjected to hydrogenation at 1,875 psi of hydrogen in the presence of 10 g of platinum oxide catalyst and at a temperature of 30 C to 50°C (variation due to exothermic reaction). The catalyst was removed by filtration and the solvent and acetic acid were distilled. The residue was taken up in water and made strongly alkaline by the addition of solid potassium hydroxide. The alkaline mixture was extracted with ether and the ether extracts dried with potassium carbonate. The product was collected by fractional distillation, BP 85°C (0.30 mm) yield 512 g (68%). [Pg.1205]

The hydrochloride salt was formed in a mixture of 1 10 isopropyl alcohol diisopropyl ether and recrystallized from acetonitrile, yield 87%, MP 124°C to 125t. [Pg.1205]

Patent 2 978,461 April 4,1961 assigned to Lakeside Laboratories, Inc. [Pg.1205]

Chemical Name N,N-dimethyl-7-phenyl-2-pyridine-propanamine maleate Common Name Prophenpyridine Structural Formula c Hj [Pg.1205]

Trade Name Manufacturer Country Year Introduced [Pg.1206]

According to U.S. Patent 2,676,964 to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of 3 limethyl-aminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over Sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid. [Pg.1206]

Sperber, N., Papa, D. and Schwenk, E. U.S. Patent 2,567,245 September 11, 1951 assigned to Schering Corporation [Pg.1206]

Chemical Abstracts Registry No- 55-S2-7 Trade Name Manufacturer [Pg.1205]


The analysis of a pharmaceutical preparation for pheniramine maleate and phenylephrine hydrochloride is described in this experiment. [Pg.448]

Pheniramine maleate Betaine hydrate Chloral betaine Beta -ionol Tretinoin Betamethasone... [Pg.1616]

Pheniramine maleate Phenyltoloxamine Thonzylamine HCI Tibezonium iodide Trimethobenzamide HCI 2otepine... [Pg.1630]

Application of 2 fractional factorial design allowed the optimization of the gradient HPLC proeednie for the determination of ibnprofen, pseudoephedrine HCl, ehlor-pheniramine maleate and nipagen in symp preparation. The optimum eonditions for this determination were found to be 3 of pH, 1.5 mL/min of flow rate, 85%, 55% and 40% of buffer eompositions of steps of gradient profde. [Pg.289]

Solution 0.5% phenylephrine hydrochloride and 0.2% pheniramine maleate (ofc) Dristan Fast Acting Formula (Whitehall-Robins)... [Pg.776]

Elixir 4 mg phenyltoloxamine citrate, 4 mg pyrilamine maleate, 4 mg pheniramine maleate per 5 mL (Rx) Poly-Histine (Sanofi-Synthelabo)... [Pg.793]

V. Das Gupta and A. G. Ghanekar, Quantitative determination of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by HPLC, J. Pharm. Sci., 66 897 (1977). [Pg.404]

D. R. Heidemann, High-pressure liquid chromatographic determination of methscopolamine nitrate, phenylpropanolamine hydrochloride, pyrilamine maleate, and pheniramine maleate in tablets, J. Pharm. Sci., 70 820 (1981). [Pg.437]

Although sedative antihistamines do not potentiate the effect of alcohol, they should be avoided in excess quantity. Overdose of astemizole can be treated with gastric lavage and supportive measures.86 Coadministration of astemizole and ter-fenadine with antiarrhythmics, antipsychotics, cisapride, and diuretics should be avoided. Chlorpheniramine maleate has been found to be incompatible with phe-nobarbitone sodium, kanamycin sulfate, and calcium chloride. Cyclizines have been used alone or with opioids in tablets or in injectable form for euphoric effects. Cyproheptadine has shown dependence in long-term use. Diphenhydramine is reported to be incompatible with amphotericin, cephalothin sodium, and hydrocortisone sodium succinate. Diphenhydramine and pheniramine maleate are sometimes used as drugs of abuse. Studies have shown that promethazine is adsorbed onto glass, plastic containers, and infusion systems.87... [Pg.345]


See other pages where Pheniramine maleate is mentioned: [Pg.1205]    [Pg.1205]    [Pg.1676]    [Pg.1685]    [Pg.1688]    [Pg.1694]    [Pg.1700]    [Pg.1700]    [Pg.1708]    [Pg.1731]    [Pg.1750]    [Pg.1750]    [Pg.682]    [Pg.216]    [Pg.168]    [Pg.168]    [Pg.2706]    [Pg.2706]    [Pg.2707]   
See also in sourсe #XX -- [ Pg.216 ]

See also in sourсe #XX -- [ Pg.77 ]




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