Cefmetazole sodium

CyDs are known to be able to solubilize lipophilic drugs as well as lipophilic absorption enhancers, leading to the improvement of the enhancer s efficiency. There are some reports on the use of CyDs as a candidate for a coenhancer. For example, Yanagi et al. [35] reported that CyDs may promote the potency of absorption enhancers in rectum of rabbits. Inclusion complex of decanoic acid (CIO), an absorption enhancer, with a-CyD was prepared as an additive of cefmetazole sodium suppository and rectally administered to rabbits. Plasma concentration and area under the curve (AUC) of cefmetazole sodium after rectal administration of a suppository containing ClO-a-CyD complex to rabbits increased more significantly than those with no additive. 

Yanagi, H., et al. 1991. Effect of inclusion complexation of decanoic acid with a-cyclodextrin on rectal absorption of cefmetazole sodium suppository in rabbits. Yakugaku Zasshi 111 65. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Haloperidol A concentrated solution of haloperidol (5 mg/mL) is incompatible with heparin sodium (in sodium chloride or glucose solutions), sodium nitroprusside (in glucose solutions), cefmetazole sodium, diphenhydramine, and sargramostim. Solutions of haloperidol precipitate if diluted with a 0.9% sodium chloride solution.158,159 Photodegradation of haloperidol could be prevented using benzyl alcohol and vanillin.160... 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

S.R. Hutching, et al., Compatibility of cefmetazole sodium with commonly used drugs during Y-site delivery. Am. J. Health Sys. Pharmacol. 53 2185-2188, 1996. 

Sekine, M., H. Terashima, K. Sasahara, K. Nishimura, R. Okada, and S. Awazu. 1985. Improvement of bio availability of poorly absorbed II. Effect of medium-chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs. J. Pharmacobio. Dyn. 8 286-295. 

Inagaki, G.M., Okamoto, M.P., and Takagi, J. (1993) Chemical compatibility of cefmetazole sodium with ranitidine hydrochloride during simulated Y-site administration, J. Parent. Sci. Technol., 47, 35-39. 

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