Sodium benzylpenicillin

Sodium benzylpenicillin see -benzylpenicillin sodium salt on p. 514 in Chapter 6. 

Chemical Nama D-a-(imidazolidin-2-on-1-yl-carbonylamino)benzylpenicillin, sodium salt Common Nama —... 

In usual practice, however, benzylpenicillin sodium is standardised against a chemical reference substance of pre-determined potency. 

The difference between the two titrations represents the volume of 0.02 N iodine equivalent to the total penicillins present in the given sample of benzylpenicillin. An assay may be carried out simultaneously by benzylpenicillin sodium (reference sample) so as to determine the exact equivalent of each ml of 0.02 N iodine. 

Calculations Calculate the potency in Units of penicillin from the declared number of Units of pencillin in benzylpenicillin sodium (reference sample). 

Materials Required Benzylpenicillin sodium (say) 0.12 g amyl acetate (previously saturated with 1-ethylpiperidinium benzylpencillin at room temperature, cooled in ice and filtered) 5.0 ml phosphoric acid (20% v/v) 0.5 ml anhydrous sodium sulphate (freshly ignited and powdered) 0.5 g dry acetone (previously saturated with 1-ethylpiperidinium benzylpenicillin at room temperature cooled in ice and filtered) 3.0 ml 1-ethylpiperidine amyl acetate solution (prepared from 1-ethyl piperidine, 1. 0 ml, and amyl acetate, 8.0 ml, saturated at room temperature with 1-ethylpiperidinium benzylpenicillin, cooled in ice and filtered) 1.5 ml dry acetone in amyl acetate (1 1) previously saturated with 1-ethylpiperidinium benzylpenicillin 2.0 ml solvent ether 4.0 ml. 

Theory Benzylpenicillin (sodium or potassium salt) may be assayed gravimetrically by quantitative conversion to the 1-ethylpiperidinium benzylpenicillin derivative. The ultimate precipitation is caused by 1-ethyl piperidine after the respective sodium or potassium salt of benzylpencillin has been duly converted with phosphoric acid to the corresponding penicillanic acid (i.e. parent acid) and the latter finally extracted with amyl alcohol. The reactions may be expressed as follows ... 

The Karl Fischer titration is used to quantify water in pharmacopoeial assays of ampicillin trihydrate, benzylpenicillin sodium, gentamycin sulphate, tetracosactrin and tobramycin. 

Semisolid Dosage Forms The nature of the base (vehicle) used for the fabrication of semisolid dosage forms affects their hydrolytic stability. Increased degradation of benzylpenicillin sodium in hydrogels of various natural and semisynthetic polymers has been reported [14]. Also at pH 6 in Carbopol hydrogels, the percentage of undecomposed pilocarpine at equilibrium is a function of the apparent viscosity of the medium [15]. 

Common Name D-a-(4-Hydroxy-l,5-naphthyridine-3-carbonamido) benzylpenicillin sodium... 

Chemical Name D-a-(Imidazolidin-2-on-l-yl-carbonylamino)benzylpenicillin, sodium salt... 

Bleomycin Bleomycin is incompatible and loses its potency if it is administered with solutions of benzylpenicillin sodium, carbenicillin, cephazolin or cephalothin sodium, hydrocortisone sodium succinate, mitomycin, methotrexate, nafcillin sodium, aminophylline, ascorbic acid, terbutaline, divalent and trivalent cations (especially copper), compounds containing sulfhydryl groups, and precipitation by hydrophobic anions, essential amino acids, riboflavine, dexamethasone, and frusemide. 

Synonyms. Crystalline Penicillin G Penicillin Penicillin G. Note. The name benzylpenicillin and its synonyms are commonly used to describe either benzylpenicillin potassium or benzylpenicillin sodium. (6i )-6-(2-Phenylacetamido)penicillanicacid Ci6Hi8N204S = 334.4 CAS—61-33-6... 

Infra-red Spectrum. Principal peaks at wavenumbers 1620,1777, 1500, 1310,1700, 703 (benzylpenicillin sodium, KBr disk). 

Benzylmorphine, 389 Benzylmorphine hydrochloride, 389 Benzylpenicillin, 390 Benzylpenicillinnovocaine, 926 Benzylpenicillin potassium, 390 Benzylpenicillin sodium, 390 Benzylphenethylamine, 376 Benzylphenoxydimethylethylamine, 896 Benzylphenylpyrrolidinylethylamine, 660 Benzyltetrahydromethylcarboline, 721... 

SYNS AMERICAN PENICILLIN BENZYL-PENICILLIN SODIUM CRYSTAPEN MYCOFARM NOVOCILLIN PEN-A-BRASIVE PENICILLIN-G, MONOSODIUM SALT PENICILLIN G, SODIUM PENICILLIN G, SODIUM SALT PENILARYN PENZYLPENICILLIN SODIUM SALT SODIUM BENZYLPENICILLIN SODIUM BENZYLPENICILLIN G SODIUM BENZYLPENICILLINATE SODIUM PENICILLIN SODIUM PENICILLIN G SODIUM PENICILLIN II VETICILLIN... 

BENZYLPENICILLIN SODIUM see BFD250 N-BENZYL-N-PHENOXYISOPROPYL-P-CHLORETHYLAMINE HYDROCHLORIDE see DDG800... 

This type of link is also found in dmgs such as chloramphenicol, ergometrine and benzylpenicillin sodium. 

Crystalline antibiotic, moderately hygroscopic. Dec 214-2 IT. [ojff +285-310 (c = 0.7). Freely sol in water, in isotonic sodium chloride soln, and in dextrose solns. Sol in methanol, ethanol, glycerol. pH of 3% aq soln 5.0 to 7.5. Solutions stored at refrigerator temps remain stable for several days. They are rapidly inactivated by acids, alkali hydroxides, and by oxidizing agents. One milligram of benzyl penicillin potassium is equivalent to 1595 units. One international Or U.S.P. penicillin unit is equivalent to 0.6 micrograms of benzylpenicillin sodium. 

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