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Amine alkylation

A second alkylation may follow converting the secondary amine to a tertiary amine Alkylation need not stop there the tertiary amine may itself be alkylated giving a qua ternary ammonium salt... [Pg.937]

PMMA is not affected by most inorganic solutions, mineral oils, animal oils, low concentrations of alcohols paraffins, olefins, amines, alkyl monohahdes and ahphatic hydrocarbons and higher esters, ie, >10 carbon atoms. However, PMMA is attacked by lower esters, eg, ethyl acetate, isopropyl acetate aromatic hydrocarbons, eg, benzene, toluene, xylene phenols, eg, cresol, carboHc acid aryl hahdes, eg, chlorobenzene, bromobenzene ahphatic acids, eg, butyric acid, acetic acid alkyl polyhaHdes, eg, ethylene dichloride, methylene chloride high concentrations of alcohols, eg, methanol, ethanol 2-propanol and high concentrations of alkahes and oxidizing agents. [Pg.262]

Pyrimidin-5-amine, 4-methylamino-synthesis, 3, 121 Pyrimidin-5-amine, 4-oxo-purfne synthesis from, 5, 582 Pyrimidinamines acylation, 3, 85 alkylation, 3, 86 basic pXa, 3, 60-61 diazotization, 3, 85 Dimroth rearrangement, 3, 86 electrophilic reactions, 3, 68 Frankland-Kolbe synthesis, 3, 116 hydrolysis, 3, 84 IR spectra, 3, 64 N NMR, 3, 64 nitration, 3, 69 Principal Synthesis, 3, 129 reactivity, 3, 84-88 structure, 3, 67 synthesis, 3, 129 Pyrimidin-2-amines alkylation, 3, 61, 86 basic pK , 3, 60 diazotization, 3, 85 hydrogenation, 3, 75 hydrolysis, 3, 84 mass spectra, 3, 66 Pyrimidin-4-amines acidity, S, 310 alkylation, 3, 61, 86 basic pXa, 3, 61 Schifi base, 3, 85 synthesis, 3, 110, 114 1,3,5-triazines from, 3, 518 Pyrimidin-5-amines basic pXj, 3, 61 hydrogenation, 3, 75 reactions... [Pg.802]

Nearly every substitution of the aromatic ring has been tolerated for the cyclization step using thermal conditions, while acid-promoted conditions limited the functionality utilized. Substituents included halogens, esters, nitriles, nitro, thio-ethers, tertiary amines, alkyl, ethers, acetates, ketals, and amides. Primary and secondary amines are not well tolerated and poor yield resulted in the cyclization containing a free phenol. The Gould-Jacobs reaction has been applied to heterocycles attached and fused to the aniline. [Pg.430]

In a variation on this approach, p-chlorobenzaldehyde is rst condensed with 2-aminopyridine. Reduction of the resulting iff base (62) affords the corresponding secondary amine. Alkyl-ion with the usual side chain affords the antihistamine, chlor-ramine (64). ... [Pg.51]

Reduction of phenylacetone in the presence of methylamine rather than ammonia gives methamphetamine (53), an agent similar in action to the primary amine. Alkylation of 53 with benzyl chloride affords the analog, benzphetamine (54). ... [Pg.70]

Quaternary ammonium salts. Salts of alkyl amines. Alkyl chain substituted cyclic amines Acidic pH range Alkaline pH range... [Pg.198]

We ve already studied the two most general reactions of amines—alkylation and acylation. As we saw earlier in this chapter, primary, secondary, and tertiary amines can be alkylated by reaction with a primary alkyl halide. Alkylations of primary and secondary amines are difficult to control and often give mixtures of products, but tertiary amines are cleanly alkylated to give quaternary ammonium salts. Primary and secondary (but not tertiary) amines can also be acylated by nucleophilic acyl substitution reaction with an acid chloride or an acid anhydride to yield an amide (Sections 21.4 and 21.5). Note that overacylation of the nitrogen does not occur because the amide product is much less nucleophilic and less reactive than the starting amine. [Pg.936]

Alkylation can also be carried out, in certain compounds, at positions a to other heteroatoms, for example, at a position a to the nitrogen of tertiary amines. Alkylation a to the nitrogen of primary or secondary amines is not generally feasible because an NH hydrogen is usually more acidic than a CH hydrogen. a-Lithiation of... [Pg.557]

Madsen and co-workers have reported an important extension to the amine alkylation chemistry, in which oxidation takes place to give the amide product [13]. A ruthenium NHC complex is formed in situ by the reaction of [RuCl Ccod)] with a phosphine and an imidazolium salt in the presence of base. Rather than returning the borrowed hydrogen, the catalyst expels two equivalents of H. For example, alcohol 31 and benzylamine 27 undergo an oxidative coupling to give amide 32 in good isolated yield (Scheme 11.7). [Pg.256]

Ethoxylated methylcarboxylates Propoxyethoxy glyceryl sulfonate Alkylpropoxyethoxy sulfate as surfactant, xanthan, and a copolymer of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate Carboxymethylated ethoxylated surfactants (CME) Polyethylene oxide (PEG) as a sacrificial adsorbate Polyethylene glycols, propoxylated/ethoxylated alkyl sulfates Mixtures of sulfonates and nonionic alcohols Combination of lignosulfonates and fatty amines Alkyl xylene sulfonates, polyethoxylated alkyl phenols, octaethylene glycol mono n-decyl ether, and tetradecyl trimethyl ammonium chloride Anionic sodium dodecyl sulfate (SDS), cationic tetradecyl trimethyl ammonium chloride (TTAC), nonionic pentadecylethoxylated nonylphenol (NP-15), and nonionic octaethylene glycol N-dodecyl ether Dimethylalkylamine oxides as cosurfactants and viscosifiers (N-Dodecyl)trimethylammonium bromide Petrochemical sulfonate and propane sulfonate of an ethoxylated alcohol or phenol Petrochemical sulfonate and a-olefin sulfonate... [Pg.198]

Alkyl methacrylates, hydrolysis of polymeric ester functionality, 259 Aluminum-hydrogen bond, nucleophilic substitution, 264 Amines alkylation, 28 benzyl-group cleavage, 25 Aminomethylation chloromethylated polymers, 19 Deltfpine reaction, 19 Anionic polymerization advantages, 85... [Pg.472]

Antioxidant. Substances that retard or inhibit autoxidation at moderate temperatures and pressures. Commonly Icnown, commercial antioxidants are aromatic amines, alkylated phenols, cresols, and hydroquinones. [Pg.391]

Kaldor [49 i, 55] demonstrated the advantages of applying solid-supported scavengers to the preparation of parallel arrays in a multi-step fashion. In these studies he examined the clean-up of multiple amine alkylation and acylation reactions using a variety of immobilized electrophilic and nucleophilic scavenger reagents including an amine, isocyanate, aldehyde and acid chloride (Tab. 2.1). [Pg.76]

Many LFe "(/u-0)(//-02CR)2Fe" L complexes have terdentate, triazamacrocyclic, or triazatri-podal ligands L. Examples include species with L = HB(pz)3, R = Me with L = tacn, R = Me with L = bis(2-benzimidazolylmethyl)amine, R = Me, Ph with L = A, A -bis(2-ethyl-5-methylimidazol-4-ylmethyl)aminopropane (213X R = Ph with L= Af-alkyl-Af,Af-bis(2-pyridyl-methyl)amine, alkyl = Me, Bz, adamantyl for R = Ph, also several other R for alkyl = Me and with L = bis((l-methylimidazol-2-yl)methyl)amine (214), R = Ph. In this last case hydrogen-bonding between lattice water and -oxo in the hydrated form results in a significant decrease in... [Pg.494]

R2 = amine, alkyl, nitrile Scheme 7.13 Halogenation of indoles by tryptophan 7-halogenase. [Pg.148]

Sulfur Compounds—Other Significant Sulfur Hexafluoride Technetium Tertiary Alcohols Tertiary Amines (Alkyl, Aryl)... [Pg.10]


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Acetylenic amines, alkylation

Acetylenic amines, alkylation preparation

Alkyl Amines Chemicals Ltd

Alkyl Halides, Alcohols, Amines, Ethers, and Their Sulfur-Containing Relatives

Alkyl Imidazoline Amines

Alkyl amines

Alkyl amines butylamine

Alkyl amines diethylamine

Alkyl amines ethylamine

Alkyl amines extraction

Alkyl amines polarization energy

Alkyl amines polyamines

Alkyl amines propylamine

Alkyl amines protonation

Alkyl amines triethylamine

Alkyl amines, tertiary

Alkyl azide, amines from reduction

Alkyl cyanide, from amines

Alkyl derivatives alkylamines, amination reactions

Alkyl dimethyl amine oxides

Alkyl groups, amines

Alkyl hahde amines from

Alkyl hahde reaction with amines

Alkyl halides amine alkylation

Alkyl halides in Gabriel synthesis of amines

Alkyl halides with amines

Alkyl hypohalites, reactions with amines

Alkyl nitrites with amines

Alkyl tert, amines, reaction with

Alkyl with amines

Alkyl, amines Homologous series

Alkyl, amines Isomerism

Alkyl, amines Names

Alkyl, amines Preparation

Alkyl, amines Properties

Alkyl, amines Synthesis

Alkyl, amines Table

Alkyl, amines anilines

Alkyl, amines cyanides

Alkyl, amines magnesium halides

Alkyl, amines phosphines

Alkyl, amines phosphonium iodides

Alkyl, amines ureas

Alkyl, amines zinc halides

Alkyl-1,5-naphthyridines amination

Alkylated Poly amine Complexes of Palladium(II)

Alkylation Reductive amination

Alkylation amine synthesis

Alkylation of Aliphatic Amines

Alkylation of Amines and Amides

Alkylation of Amines by Alkyl Halides

Alkylation of Amines with Alcohols

Alkylation of amines

Alkylation of ammonia and amines

Alkylation of an amine

Alkylation of primary amines

Alkylation of secondary amines

Alkylation with alkyl amines

Alkylation with amines and ammonium salts

Alkylation, enolate ions Amines

Alkylative amination

Alkylative amination

Alkylative amination aldehydes

Alkylative amination alkyltitanium complexes

Aminals alkylation reactions, pyrrolidine

Amination alkyl groups

Amination alkylation of aldehydes

Amination with Alkyl Nitrates

Amination with Alkyl Nitrites

Amine Synthesis by A-Alkylation

Amine alkyl dimethyl

Amine arenesulfonate alkyl ester

Amine from alkyl azides

Amine hydrazine alkyl

Amine oxides alkyl distribution

Amine oxides alkyl iodide oxidation

Amine oxides and alkyl halides

Amine phosphate alkyl ester

Amine triflate alkyl ester

Amine, N-alkyl

Amines Eschweiler-Clark reductive alkylation

Amines Leuckart-Wallach alkylation

Amines N-alkylation

Amines Organic bases derived from ammonia alkylation

Amines alkyl halides

Amines alkylation of ammonia

Amines alkylation reactions

Amines alkylation with olefins

Amines aromatic, alkylation

Amines aryl, alkylation

Amines by reductive alkylation

Amines from alkyl halides

Amines from by reductive alkylation

Amines heteroaromatic, alkylation

Amines palladium-catalyzed alkylation

Amines reductive alkylation

Amines, a-alkylation

Amines, acetylation alkylation

Amines, alkyl halides and

Amines, alkylation Delepine reaction

Amines, alkylation catalyst

Amines, alkylation shape selectivity

Amines, alkylation with alcohols

Amines, allylic, carbanions alkylation

Amines, homoallylic alkylation

Ammonium formate reductive alkylation of amines

Ammonium salts, alkyl amines

And alkylation of amines

Aromatic amines alkyl anilines

Aryl alkyl ketones reductive amination

Asymmetric Alkylation or Amination of Allylic Esters

Asymmetric Allylic Amination and Alkylation

Asymmetric Friedel-Crafts alkylation reactions amination

Borrowing hydrogen amine alkylation

Clark-Eschweiler reductive alkylation of amines

Diazo compounds, alkylation amines

Dimethylaniline amines :alkyl anilines

Electrophilic amination Friedel-Crafts alkylation

Enamines, alkylation from amines

Eschweiler reductive alkylation of amines

Eschweiler-Clarke reductive alkylation amines

Eschweiler-Clarke reductive alkylation of amines

Ethoxylated alkyl amines

For alkylation of amines

Formamide //-alkyl amine

Halides, alkyl reaction with amines

Halides, alkyl, preparation from amines

Halo amines, alkylation

Halo amines, alkylation preparation

Hexamethylenetetramine, amine alkylation

Higher alkyl amines

Hofmann alkylation of ammonia and amines

Hydroxy amines reductive alkylation

Hydroxy halides, alkylation amination

Hypochlorites, alkyl sodium, with amines

INDEX Alkyl amine

Iridium-Catalyzed Alkylation of Alcohols with Amines

Ketenes, p- aminals alkylation

Lactams, alkylation amines

Long-chain alkyl amine

Methylaniline amines:alkyl anilines

N-Alkylation of Amines with Alcohols

N-alkylation of amines

Other Alkyl Amines

Preparation of Alkyl Amines

Preparation of Amines by Reductive Alkylation

Primary alkyl amines

Primary amines, alkylation

Quaternary amines alkyl quats

Quinolines, alkylation amination

Reaction of Amines with Alkyl Halides

Reductive Alkylation of Primary Amines with Carbonyl Compounds

Reductive alkylation amine precursors

Reductive alkylation of amines

Reductive alkylation secondary amine formation

Reductive alkylation tertiary amine formation

Reductive aminations alkylations

Secondary amines alkylation

Secondary amines, from reductive alkylation

Secondary amines, from reductive alkylation amination)

Subject amine alkylation

Substituted alkyl pyrimidine amines

Sulfonates amine alkylation

Synthesis of Amines by Alkylation

Tertiary amines alkylation

Tertiary amines, from reductive alkylation

Tertiary amines, from reductive alkylation amination)

Tertiary-alkyl primary amines

The Physical Properties of Alkanes, Alkyl Halides, Alcohols, Ethers, and Amines

The Structures of Alkyl Halides, Alcohols, Ethers, and Amines

Thiocarboxylates, 0-alkyl amines

Triphenylmethyl chloride, amine alkylations

Vinyl alkyl amines

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