Preparation of Alkyl Amines

For the stereoselective formation of diastereomeric products, it was recognized at an early stage that the U-4CR can proceed stereoselectively if chiral primary amines and aldehydes are employed as the reactive components. The peptide derivatives 17 can only be formed if the amino component 14 contains an alkyl group that can be replaced by a proton in 16 producing 17 (Scheme 3).P l The essential problems were first solved separately by a variety of experimental investigations.It was found that chiral, a-ferrocenyl-substituted alkyl-amines 18 are able to fulfill all the requirements of peptide synthesis by stereoselective U-4CRs (Scheme 4).hi New, efficient methods were developed for the preparation of alkyl-amines in order to investigate their role in the synthesis of peptide derivatives by the... 

Preparation of Alkyl Amines. The main application of the electrophilic animation of aliphatic carbanions is in the preparation of hindered amines. These... 

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