Asymmetric Alkylation or Amination of Allylic Esters

1 Synthesis and application in palladium-catalysed asymmetric allylic substitution 

Maria Zablocka, Marek Koprowski, Jean-Pierre Majoral, Matmeu Achard 

DIYL)BIS[(4S)-4-PHENYL-2-OXAZOLINE] AS A LIGAND FOR ASYMMETRIC PALLADIUM-CATALYSED ALKYLATION OF ALLYLIC ACETATES IN FLUOROUS MEDIA 

3 Facile synthesis of new axially chiral diphosphine complexes for asymmetric 

Matthias Lotz, Gernot Kramer, Katja Tappe and Paul Knochel. 47 

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Catalytic reactions of allylic electrophiles with carbon or heteroatom nucleophiles to form the products of formal S 2 or S 2 substitutions (Equation 20.1) are called "catalytic allylic substitution reactions." Tliese reactions have become classic processes catalyzed by transition metal complexes and are often conducted in an asymmetric fashion. The aUylic electrophile is typically an allylic chloride, acetate, carbonate, or other t)q e of ester derived from an allylic alcohol. The nucleophile is most commonly a so-called soft nucleophile, such as the anion of a p-dicarbonyl compound, or it is a heteroatom nucleophile, such as an amine or the anion of an imide. The reactions with carbon nucleophiles are often called allylic alkylations. 

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