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Kolbe synthesis

The key compound m the synthesis of aspirin salicylic acid is prepared from phe nol by a process discovered m the nineteenth century by the German chemist Hermann Kolbe In the Kolbe synthesis also known as the Kolbe—Schmitt reaction, sodium phen oxide IS heated with carbon dioxide under pressure and the reaction mixture is subse quently acidified to yield salicylic acid... [Pg.1006]

Pyrimidin-5-amine, 4-methylamino-synthesis, 3, 121 Pyrimidin-5-amine, 4-oxo-purfne synthesis from, 5, 582 Pyrimidinamines acylation, 3, 85 alkylation, 3, 86 basic pXa, 3, 60-61 diazotization, 3, 85 Dimroth rearrangement, 3, 86 electrophilic reactions, 3, 68 Frankland-Kolbe synthesis, 3, 116 hydrolysis, 3, 84 IR spectra, 3, 64 N NMR, 3, 64 nitration, 3, 69 Principal Synthesis, 3, 129 reactivity, 3, 84-88 structure, 3, 67 synthesis, 3, 129 Pyrimidin-2-amines alkylation, 3, 61, 86 basic pK , 3, 60 diazotization, 3, 85 hydrogenation, 3, 75 hydrolysis, 3, 84 mass spectra, 3, 66 Pyrimidin-4-amines acidity, S, 310 alkylation, 3, 61, 86 basic pXa, 3, 61 Schifi base, 3, 85 synthesis, 3, 110, 114 1,3,5-triazines from, 3, 518 Pyrimidin-5-amines basic pXj, 3, 61 hydrogenation, 3, 75 reactions... [Pg.802]

The Kolbe synthesis of nitriles is an important method for the elongation of an alkyl chain by one carbon center (see also the Arndt-Eistert synthesis). The nitrile 2 can for example easily be converted to the corresponding carboxylic acid by hydrolysis. [Pg.184]

Kolbe synthesis of an alkyl a,cu-dicar-boxylate, 21, 48 KrYPTOPYRROLE, 21, 67... [Pg.57]

Eicosanedioic add, 43, 39 Electrolysis, Kolbe synthesis, of 2,7-(Jhnethyl-2,7-dinitro6ctane, 41,... [Pg.59]

Hydroxy-3-naphthoic acid ( BONA or BON ) is prepared by heating the sodium salt of 2-hydroxynaphthalene with carbon dioxide in a pressure chamber at 240 to 250°C at a pressure of 15 bar (Kolbe synthesis). The reaction mixture is continuously agitated. Remaining 2-naphthol is separated and recycled ... [Pg.190]

Kolbe-Schmitt Reaction (Kolbe Synthesis, Schmitt Synthesis)... [Pg.374]

It is therefore intriguing to understand what is the particular role of the platinum/electrolyte interface in the Kolbe synthesis favoring that reaction path—Eqs. (39a)-(39c)—which is thermodynamically disfavored and unlikely to occur. A closely related reaction whose kinetics are easier to investigate with conventional electrode kinetic methods is the anodically initiated addition of N3 radicals to olefins, discovered by Schafer and Alazrak (275). The consecutive reactions, which follow the initial generation of the reactive intermediate, an Na radical, are somewhat slower than that of the Kolbe radicals, so that their rate influences the shape and potential of the current voltage curves which can be evaluated in terms of reaction rates and rate laws. [Pg.160]

Contrary to the noncatalytic Kolbe synthesis or other anodically initiated radical reactions at Pt anodes, the anodic functionalization and anodic coupling of vinyl compounds by direct anodic oxidation of olefins in alcohols as... [Pg.162]

Cells such as those described in References 23, 24, and 29 are particularly suited to study of short-lived intermediates requiring in situ generation at accurately controlled potentials. When a conventional electrochemical cell was used to study the Kolbe synthesis oxidation of triphenylacetic acid [53], it was concluded that the initially formed radical was triphenylacetoxyl (3-CCOO ), based on the assignment of two para- and four ortho-proton splittings. A more careful study [54] using the cell described in Reference 23 showed that it is in fact the triphenylmethyl radical that is formed initially the identity of the other species was not established, although it is clearly not the acetoxyl radical. [Pg.946]

It is an interesting fact that if potassium phenolate is used in the Kolbe synthesis para-hydroxy benzoic acid is obtained, especially at high temperatures. Potassium phenyl carbonate is first formed, and heated up to 150° yields salicylic acid, but if the temperature be further raised, the para-acidis produced in increasing quantities until at 220° potassium para-hydroxy-benzoic acid is the sole product. [Pg.116]

The reaction principle of the Kolbe synthesis can be extended both to higher carboxylic acids (e.g. methyl suberate228)) and to the dimerization of two different carboxylic acids (cross Kolbe coupling). A few examples of syntheses studied on the laboratory scale are listed below. [Pg.26]

A. Crum-Brown and J. Walker, Justus Liebigs Am. Chem. 261 107 (1891). Kolbe synthesis. [Pg.118]

Brown-Walker reaction — Important generalization and extension of the Kolbe reaction (1891) (- Kolbe synthesis) leading to the synthesis of a variety of long-chain dicarboxylic acids and esters using monoesters of dicar-boxylic precursors. Among the most used application belongs the production of sebacic acid diethylester from hydrogen ethyladipate... [Pg.60]

A two-electron variation (1902) of the Kolbe reaction (-> Kolbe synthesis) Salts of aliphatic acids (carboxylate... [Pg.335]

Kolbe synthesis — The definition and use of the terms - Kolbe synthesis, K. reaction, K. electrolysis, and K. process are not very clearly distinguished and often bear different nuances of meaning. Kolbe electrolysis or synthesis mainly accounts for the anodic oxidation of carboxylic acids or carboxylates, followed by a decarboxylation step, when concentrated aqueous solutions of the respective carboxylates are electrolyzed. Kolbe picked up earlier results from -> Faraday on the electrolysis of acetic acid or acetate solutions to CO2 and ethane [i] and continued these experiments during 1843-1845 with further homologs as, e.g., valerianic acid [ii]. The carboxy-late R-COO- is anodically oxidized to form an unstable radical R-COO, which is stabilizing via a decarboxylation reaction, leaving radical rest R ... [Pg.386]

Eventually, the formed alkyl radical(s) dimerize forming an alkane R-R (with an even number of C atoms), if high current densities and high radical concentration are provided. The Kolbe synthesis can be used for the build-up of higher saturated hydrocarbons or fatty acids, or longer-chain diester compounds. [Pg.386]


See other pages where Kolbe synthesis is mentioned: [Pg.239]    [Pg.116]    [Pg.184]    [Pg.184]    [Pg.113]    [Pg.92]    [Pg.184]    [Pg.184]    [Pg.111]    [Pg.57]    [Pg.116]    [Pg.99]    [Pg.1360]    [Pg.438]   
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See also in sourсe #XX -- [ Pg.857 , Pg.858 ]

See also in sourсe #XX -- [ Pg.231 ]




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Aromatic Kolbe-Schmitt synthesis

Electrolysis, Kolbe synthesis, of 2,7dimethyl-2,7-dinitrooctane

Electrolysis, Kolbe synthesis, of 2,7dimethyl-2,7-dinitrooctane two-compartment cell for

Electroorganic synthesis Kolbe reaction

Formation of Aromatic Carboxylic Acids The Kolbe-Schmitt Synthesis

Industrial applications Kolbe—Schmitt synthesis

KOLBE SCHMIDT Salicylic acid synthesis

Kolbe

Kolbe electrolytic synthesis

Kolbe nitrile synthesis

Kolbe reaction synthesis

Kolbe synthesis of nitriles

Kolbe-Schmitt synthesis

Kolbe-type synthesis

Kolbes salicylic acid synthesis

Kolbe’s synthesis

Process Kolbe-Schmitt synthesis

Processing Kolbe-Schmitt synthesis

Reaction Parameters and Mechanistic Studies of the Kolbe-Schmitt Synthesis

Salicylic acid Kolbe synthesis

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