Amines methyl

Meihylamine hydrochloride method. Place 100 g. of 24 per cent, methyl-amine solution (6) in a tared 500 ml. flask and add concentrated hydrochloric acid (about 78 ml.) until the solution is acid to methyl red. Add water to bring the total weight to 250 g., then introduce lSO g. of urea, and boil the solution gently under reflux for two and three-quarter hours, and then vigorously for 15 minutes. Cool the solution to room temperature, dissolve 55 g. of 95 per cent, sodium nitrite in it, and cool to 0°. Prepare a mixture of 300 g. of crushed ice and 50 g. of concentrated sulphuric acid in a 1500 ml. beaker surrounded by a bath of ice and salt, and add the cold methylurea - nitrite solution slowly and with mechanical stirring and at such a rate (about 1 hour) that the temperature does not rise above 0°. It is recommended that the stem of the funnel containii the methylurea - nitrite solution dip below the surface of the acid solution. The nitrosomethylurea rises to the surface as a crystalline foamy precipitate. Filter at once at the pump, and drain well. Stir the crystals into a paste with about 50 ml. of cold water, suck as dry as possible, and dry in a vacuum desiccator to constant weight. The yield is 55 g. (5). 

Determine the methylamine content of the commercial solution by titration with standard acid using methyl orange as indicator. Adjust the quantity of methyl-amine solution in accordance with the methylamine content for some commercial samples, the figure may be 33-40 per cent. 

You can examine the structure of methyl amine including its electrostatic potential map in more detail on Learning By Modeling... 

The Leuckart reaction uses formic acid as reducing agent. Reductive alkylation using formaldehyde, hydrogen, and catalyst, usually nickel, is used commercially to prepare methylated amines. These tertiary amines are used to prepare quaternary ammonium salts. 

Fig. 3. Synthesis of fluoxetine (31). 3-ChIoro-I-phenyl-I-propanol reacts with sodium iodide to afford the corresponding iodo derivative, followed by reaction with methylamine, to form 3-(methyl amin o)-1-phenyl-1-propan 0I. To the alkoxide of this product, generated using sodium hydride, 4-fluorobenzotrifluoride is added to yield after work-up the free base of the racemic fluoxetine (31), thence transformed to the hydrochloride (51)...

L-Fohc acid (1) contains three subunits 6-methylpterin, -aminobenzoic acid, and L-glutamic acid. The Chemicaly hstracts name is A/- [4- [ (2-amino-l,4-dihydro-4-oxo-6-pteridinyl)methyl amin o]benzoy1]-T-glutamic acid. 

Purine, 6-methoxy-9-methyl-hydrolysis, 5, 558 Purine, 1-methyl- H NMR, 5, 511 synthesis, 5, 594 Purine, 2-methyl-amination, 5, 542 mass spectra, 5, 519 synthesis, 5, 593 Purine, 3-methyl- H NMR, 5, 511 occurrence, 5, 598 synthesis, 5, 586, 595 Purine, 6-methyl-amination, 5, 542 mass spectra, 5, 519 methylation, 5, 529 oxidation, 5, 539 1-oxide... 

Amines or amides Alkyl amines (iindecyloctyl and diamyl methyl amine) polyamides (acyl derivatives of piperazine) Boiler foam sewage foam fermentation dye baths... 

Fractionally distd under vacuum, then fractionally crystd twice from its melt. Impurities include acetic acid, methyl amine and H2O. For detailed purification procedure, see Knecht and Kolthoff, Inorg Chem 1 195 1962. Although /9-methylacetamide is commercially available it is often extensively contaminated with acetic acid, methylamine, water and an unidentified impurity. The recommended procedure is to synthesise it in the laboratory by direct reaction. The gaseous amine is passed into hot glacial acetic acid, to give a partially aq soln of methylammonium acetate which is heated to ca 130° to expel water. Chemical methods of purificatn such as extractn by pet ether, treatment with H2SO4, K2CO3 or CaO can be used but are more laborious. 

Let us define the respective basicity by — AG in the gas phase and — AG" in aqueous solution. For discussions concerning the relative strength in basicity of a series of methyl-amines, only the relative magnitudes of these quantities are needed. Thus the free energy changes associated with the protonation of the methylamines relative to those of ammonia are defined as... 

The amines are a group of compounds with the general formula R-NHj, and all the common amines are hazardous. As a class the amines pose more than one hazard, being flammable, toxic, and, in some cases, corrosive. The amines are an analogous series of compounds and follow the naming pattern of the alkyl halides and the alcohols that is, the simplest amine is methyl amine, with the molecular formula of CH NHj. Methyl amine is a colorless gas with an ammonia-like odor and an ignition temperature of 806°F. It is a tissue irritant and toxic, and it is used as an intermediate in the manufacture of many chemicals. Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its isomers, and so on. 

Methyl Amine + a-Naphthol Chloroformate = Carbaryl -I- Hydrogen Chloride,... 

The following synthesis of p ewdopelletierine is of special interest, since it involves only materials and conditions which could occur in plants and is therefore a possible bio-synthesis. Menzies and Robinson showed that when calcium acetonedicarboxylate, glutardialdehyde and methyl-amine are mixed in aqueous solution under specified conditions and the mixture is kept for twenty-four hours, a produet (XX) is formed, which can be decarboxylated to -pelletierine (XXI) and the latter isolated as the picrate, whieh after recrystallisation yields the pure base (m.p. 48-5°), the identity of which can be established by eonversion to the characteristic dipiperonylidene derivative. The course of the synthesis is represented as follows — ... 

See Methyl methacrylate monomer also Mono-methyl amine (Methylamines)... 

C) 10 g of 6-chloromethyl-morphanthridine are passed into 150 ml of a solution of methyl-amine in benzene (10%). After storage of the solution for 20 hours at 0° to 5°C the methyl-amine hydrochloride formed is sucked off and the filtrate evaporated to dryness. There remains as residue 11 g of crude 6-methylaminomethyl-morphanthridine. 

Phenylsuccinic anhydride Methyl amine Acetyl chloride... 

Strategy Look at the target molecule, and identify the groups attached to nitrogen. One of the groups must be derived from the aldehyde or ketone component, and the other must be derived from the amine component. In the case of iV-methyl-2-phenylcthyl-arnine, there are two combinations that can lead to the product phenvjacetaldehyde plus methylamine or formaldehyde plus 2-pbenylethylamine. In general, it s usually better to choose the combination with the simpler amine component—methyl-amine in this case—and to use an excess of that amine as reactant. 

The liquid anion exchangers at present available are based largely on primary, secondary and tertiary aliphatic amines, e.g. the exchangers Amberlite LA.l [A/-dodecenyl(trialkylmethyl)amine] and Amberlite LA.2 [A/-lauryl(trialkyl-methyl)amine], both secondary amines. These anion exchange liquids are best employed as solutions (ca 2.5 to 12.5% v/v) in an inert organic solvent such as benzene, toluene, kerosene, petroleum ether, cyclohexane, octane, etc. 

An interesting question is the effect of unshared pairs of electrons on an axial atom. Pauling states that they appear to contribute little to three fold barriers, basing this on the observed fact that methyl amine with two N—H bonds and one pair has about 2/3 the barrier of ethane while methyl alcohol with one O—H bond and two pairs has approximately one third the ethane value. He explains this by pointing out that the unshared pairs, not forming bonds, have not the same reason to acquire / character, without which they will not contribute to a threefold barrier. 

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