Clarke-Eschweiler reductive alkylation of amines

Reductive methylation of primary or secondary amines using formaldehyde and formic acid. Cf. Leuckart-Wallach reaction. 

Name Reactions, 4th ed., DOI 10.1007/978-3-642-01053-8 91, Springer-Verlag Berlin Heidelberg 2009 

8 Brewer, A. R. E. Eschweiler-Clarke reductive alkylation of amine. In Name Reactions for Functional Group Transformations-, Li, J. J., Corey, E. J., eds. John Wiley Sons Hoboken, NJ, 2007, pp 86-111. (Review). 

Name Reactions A Collection of Detailed Mechanisms and Synthetic Applications DOI 10.1007/978-3-319-03979-4 98, Springer International Publishing Switzerland 201 

Asymmetric aldol reaction of aldehyde and chiral acyl oxazolidinone, the Evans chiral aitxihary. 

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Amine synthesis from reductive amination of a ketone and an amine in the presence of excess formic acid, which serves as the reducing reagent by delivering a hydride. When the ketone is replaced by formaldehyde, it becomes Eschweiler-Clarke reductive alkylation of amines. 

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