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Subject amine alkylation

The synthesis, physical and chemical properties of sulphamides have been the subject of various reviews down through the years333-338. Sowada339 has summarized the three main synthetic routes in the preparation of sulphamides as follows (a) reaction of primary amines (alkyl or aryl) with sulphuryl chloride (b) reaction of primary amines with chlorosulphonic acid (c) reaction of primary amines (alkyl, cycloalkyl and aryl) with sulphamide. [Pg.1004]

Stability. In order to have maximum effectiveness over long periods of time, an antioxidant should be stable upon exposure to heat, light, oxygen, water, etc. Many antioxidants, especially in the presence of an impurity when exposed to light and oxygen, are subject to oxidation reactions with the development of colored species. Alkylated diphenyl amines are least susceptible and the -phenylenediamine derivatives the most susceptible to direct oxidation. [Pg.246]

Benzylic quaternary ammonium salts, when treated with alkali metal amides, undergo a rearrangement called the Sommelet-Hauser rearrangementSince the product is a benzylic tertiary amine, it can be further alkylated and the product again subjected to the rearrangement. This process can be continued around the ring until an ortho position is blocked. ... [Pg.877]

Sulfate monoesters can react by dissociative paths, and this is the favored path. Whether such reactions are concerted or involve a very short-lived sulfur trioxide intermediate has been the subject of debate. ° Benkovic and Benkovic reported evidence suggesting that the nucleophile is present (though there is little bond formation) in the transition state for the reaction of amines with p-nitrophenyl sulfate. Alkyl esters of sulfuric or sulfonic acids normally react with C-0 cleavage only when this is disfavored, as in aryl esters, does one see S-0 cleavage. Sulfate diester... [Pg.23]

In this study we examine the generalities in reductive alkylation however, since the subject is vast, we limited ourselves to the interaction of aromatic and aliphatic primary amines and diamines with ketones. The ketones examined include the cyclic ketone, cyclohexanone, and aliphatic ketones such as acetone, and methyl isobutyl ketone (MIBK). We limited our study to sulfided and unsulfided Pt and Pd catalysts supported on activated carbon that were commercially available from Evonik Degussa Corporation. [Pg.160]

Oxidative attack on a carbon-hydrogen bond of an alkyl group a to a nitrogen atom is not restricted to saturated aliphatic amines. In fact X in an X-N-CH- structural subunit can be virtually any common atomic grouping that can be found in stable organic molecules. For example, w-carbon hydrogens of Aralkyl-substituted aromatic cyclic amines (119), aryl amines (120), amides (121), amidines (122), A-nitrosodialkylamines (123), etc. are all subject to oxidative attack, carbinolamine formation, and in most cases release of an aldehyde or ketone depending on the substitution pattern (1° or 2°)... [Pg.79]

The simplicity of the two-phase modification of the Gabriel synthesis of primary amines, via the N-alkylation of potassium phthalimide, makes the procedure considerably more convenient than the traditional method, which normally requires the use of anhydrous dipolar aprolic solvents. The reaction can be conducted under solid liquid conditions using potassium hydroxide in toluene [25], or with preformed potassium phthalimide [26, 27] (cf ref. 28). As is normal for acylation reactions, relatively mild conditions are required for the preparation of the A-ethoxycarbonyl derivative [29], whereas a reaction temperature of 100°C is generally used for N-alkylation (Table 5.16). The reaction time for the soliddiquid two-phase system can be reduced dramatically with retention of the high yields, when the reaction mixture is subjected to microwave irradiation [30]. [Pg.180]

The range of organic compounds which have been subject to the Simons process is wide and includes aliphatic and aromatic hydrocarbons, halocarbons, ethers, aliphatic and aromatic amines, heterocyclics, thiols, alkyl sulphonic and carboxylic acids, and their derivatives, among others. [Pg.214]


See other pages where Subject amine alkylation is mentioned: [Pg.420]    [Pg.199]    [Pg.419]    [Pg.459]    [Pg.207]    [Pg.383]    [Pg.119]    [Pg.256]    [Pg.223]    [Pg.226]    [Pg.230]    [Pg.61]    [Pg.70]    [Pg.419]    [Pg.40]    [Pg.350]    [Pg.372]    [Pg.213]    [Pg.703]    [Pg.154]    [Pg.824]    [Pg.110]    [Pg.105]    [Pg.308]    [Pg.203]    [Pg.1168]    [Pg.483]    [Pg.853]    [Pg.772]    [Pg.659]    [Pg.140]    [Pg.574]    [Pg.566]    [Pg.856]    [Pg.248]    [Pg.492]    [Pg.207]    [Pg.673]    [Pg.89]    [Pg.319]    [Pg.207]    [Pg.807]    [Pg.250]   
See also in sourсe #XX -- [ Pg.74 ]

See also in sourсe #XX -- [ Pg.74 ]




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Alkylative amination

Amines alkylation

Subject alkylation

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