Oil Sesame

PhEur Sesami oleum raffinatxim USPNF Sesame oil 

Benue oil gingelly oil gingili oil jinjili oil Lipovol SES teel oil. 

A typical analysis of refined sesame oil indicates the composition of the acids, present as glycerides, to he arachidic acid 0.8% linoleic acid 40.4% oleic acid 45.4% palmitic acid 9.1% and stearic acid 4.3%. Sesamin, a complex cyclic ether, and sesamolin, a glycoside, are also present in small amounts. 

Note that other reported analyses may vary slightly from that above. 

The monographs for Sesame Oil in the USPNF 23 and Refined Sesame Oil in the PhEur 2005 specify the acceptable range of eight triglycerides found in sesame oil. 

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Dronabinol. Marinol ( ii7R-/n7 j )-6i7,7,8,I0i7-tetrahydro-6,6,9-trimethyl-3-pentyl-6JT-diben2o(B,D) pyran-I-ol is the principal psychoactive substance present in Cannabis sativa F., ie, marijuana. It is a controlled substance, formulated in sesame oil and encapsulated in soft gelatin capsules for oral adrninistration. 

Sesam, m. sesame, -knorpel, m. sesamoid cartilage. -kuchen, m. sesame (oil) cake, -ol, n. sesame oil. -saat, /. sesame seed. Sesquiozyd, n. sesquioxide. 

Septisol liquid soap 8 drops Olive or sesame oil 0.25%... 

Certain small-volume injections are available where the dmg is dissolved in a viscous oil because it is insoluble in water non-aqueous solvent must be used, hi addition, drags in non-aqueous solvents provide a depot effect, for example for hormonal compounds. The intramuscular route of injection must be used. The vehicle may be a metabolizable fixed oil such as arachis or sesame oil (but not a mineral oil) or an ester such as ethyl oleate which is also metabolizable. The latter is less viscous and therefore easier to administer but the depot effect is of shorter duration. The dmg is normally dissolved in the oil, filtered under pressure and distributed into ampoules. After sealing, the ampoules are sterilized by dry heat, for example, at 160°C for 2 hours. A bactericide is probably ineffective in such a medium and therefore offers very httle protection against contamination in a multidose oily injection. 

On the market are two drugs imder the trade names of Dronabinol, which is the generic name of trans-A9-THC, and Marinol, which is a medicine containing synthetic dronabinol in sesame oil for oral intake, distributed by Unimed Pharmaceuticals. 

In contrast to the C. sativa tincture, Marinol soft gel capsules possess clear advantages. Firstly, they contain a single component in an accurate dosage. Secondly, it uses sesame oil as the carrier, making resorption significantly more reliable and also stabilizing the rather sensitive THC molecule. 

Monoolein will also form the cubic phase together with lecithin (e.g. dioleoyl phosphatidylcholine, see Figure 1), but above about 50% (w/w) lecithin the cubic phase is transformed into the lamellar phase (2). Moreover, water may be replaced by glycerol, completely or partly, in the cubic phase. Vegetable oils, e.g. sesame oil, can be incorporated to some extent (a few percent) in the cubic phase, and the same holds for bile salts. 

A major class of nonaqueous solvents is the fixed oils. The USP [1] recognizes the use of fixed oils as parenteral vehicles and lists their requirements. The most commonly used oils are corn oil, cottonseed oil, peanut oil, and sesame oil. Because fixed oils can be quite irritating when injected and may cause sensitivity reactions in some patients, the oil used in the product must be stated on the label. 

Sesame oil is the preferred oil for most of the official injections in oil. This is because it is the most stable (except in light) and, thus, will usually meet the official requirements. Fixed oils must never be administered intravenously and are, in fact, restricted to IM use. 

The USP usually does not specify an oil, but states that a suitable vegetable oil can be used. The main use of such oils is with the steroids, with which they yield products that produce a sustained-release effect. Sesame oil has also been used to obtain slow release of fluphenazine esters given intramuscularly [14], Excessive unsaturation of an oil can produce tissue irritation. The use of injections in oil has diminished... 

When oils are used as vehicles in ophthalmic fluids, they must be of the highest purity. Vegetable oils such as olive oil, castor oil, and sesame oil have been used for extemporaneous compounding. These oils are subject to rancidity and, therefore, must be used carefully. Some commercial oils, such as peanut oil, contain stabilizers that could be irritating. The purest grade of oil, such as that used for parenteral products, would be advisable for ophthalmics. 

Vegetable oils and dairy and animal fats were used extensively in ancient times in cookery, for lighting, and as ingredients of cosmetics, balms and medications [21 29]. Olive, almond, balanos, castor, coconut, linseed, moringa, palm, poppy, radish, safflower, and sesame oils were well known oleiferous species in the Mediterranean [21,30], Data on... 

Basu and Nath (59), studied calcium absorption in young men eating diets varied in levels of calcium. Diets were either nearly fat-free or contained fat supplied primarily by butterfat, sesame oil, peanut oil, coconut oil or mustard seed oil. Feeding of all test fats except coconut oil resulted in a slight decrease in fecal calcium, thus, an assumed increase in calcium bioavailability. However, feeding of coconut oil (a highly saturated fat) resulted in increased fecal and urinary losses of calcium. 

He shou wu, a herhal formulation has been used for the treatment of skin tumors. For topical use, the powder is mixed with sesame oil and applied. He shou wu has been used for centuries to help maintain the youthful color of one s hair and also to help diminish hair loss. Holy basil contains ursolic acid (Fig. 7) — one of the cosmetic industry s latest favorites because not only does it quickly heal the skin, it also improves elasticity and removes wrinkles. It also shows benefits for preventing skin cancer. A poultice made from the herh is used topically for its antifungal and antibacterial actions. ... 

In an experiment on humans to evaluate the primary skin irritating and skin sensitizing potential of ronnel, 50 subjects received three applications/week for 3 weeks of gauze saturated with a 10% suspension of ronnel in sesame oil there were no significant effects on the skin. ... 

CN034 Salerno, J. W. and D. E. Smith. The use of sesame oil and other vegetable oils in the inhibition of human colon cancer growth in vitro. Anticancer Res 1991 11(1) 209-215. 

CN097 Satchithanandam, S., M. Reicks, R. J. Calvert, M. M. Cassidy, and D. Kritchevsky. Coconut oil and sesame oil affect lymphatic absorption of cholesterol and fatty acids in rats. J Nutr 1993 123(11) 1852-1858. 

Effect of excessive intake of thermally CN158 oxidized sesame oil on lipids, lipid peroxidation and antioxidants status in rats. Indian J Exp Biol 2000 38(8) ... 

Antitoxic effect. Sesame oil, adiministered to male Wistar rats, ameliorated hepatic and renal damage in a dose-dependent manner and increased survival in lipopolysaccha-ride-treated rats. It decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion, and the activity of xanthine oxidase was reduced in the lipopolysaccharide-challenged rats k Anti-tumor activity. Water extract of the dried seed, administered intragastrically to mice at a dose of 50 mg/animal daily for 5 days, was active on CA-Ehrlich-ascites, 18% increase in life-span. Intraperitoneal administration was active on Dalton s lyphoma and CA-Ehrlich-ascites, 19 and 39% increase in life-span, respectively ". Seed oil, administered to rats intraperito-neally with 1,2,5,6-dibenzanthracene or re-tene, was active on sarcoma ". 

Hemotoxic activity. Seed oil, administered orally to human adults, produced thrombocytosis in children, the effect was inactivated by ultraviolet radiation . Hypercholesterolemic activity. Seed oil, administered by gastric intubation to rabbits at a dose of 0.4 g/kg, was inactive " . Male Wistar rats fed 12 or 24% sesame oil in the diet for 4 weeks were investigated. The rats on the 24% sesame oil diet had significantly lower lymphatic cholesterol and fatty acids . 

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