In sesame oils

Dronabinol. Marinol ( ii7R-/n7 j )-6i7,7,8,I0i7-tetrahydro-6,6,9-trimethyl-3-pentyl-6JT-diben2o(B,D) pyran-I-ol is the principal psychoactive substance present in Cannabis sativa F., ie, marijuana. It is a controlled substance, formulated in sesame oil and encapsulated in soft gelatin capsules for oral adrninistration. 

On the market are two drugs imder the trade names of Dronabinol, which is the generic name of trans-A9-THC, and Marinol, which is a medicine containing synthetic dronabinol in sesame oil for oral intake, distributed by Unimed Pharmaceuticals. 

In an experiment on humans to evaluate the primary skin irritating and skin sensitizing potential of ronnel, 50 subjects received three applications/week for 3 weeks of gauze saturated with a 10% suspension of ronnel in sesame oil there were no significant effects on the skin. ... 

Malten, W. G. Van Ketel, and E. Van SI107 Dijk. Allergens in sesame oil contact dermatitis. Acta Derm 1975 55 31-34-... 

Oommachan, M., and S. S. Khan. Plants in aid of family planning programme. Sci Life 1981 1 64-66. Yoshida, M., and T. Kashimoto. Determination of sesamolin, sesamin and sesamol in sesame oil by high-performance liquid chromatography. Shokuhin Eiseigaku Zasshi 1982 23 142-148. 

Kato, Y., E. Ueda, T. Kyoko, A. Yukiyo Nagaoka, S.Iwashita, S. Ninomiya, and N. Kato. Asarinin in sesame oil. Pharmazie 1980 35(12) 808-809. Dixit, R. S., And H. G. Pandey. Plants used as folk medicine in Jhansi and Lalitpur sections of Bundelkhand, Uttar Pradesh. Int J Crude Drug Res 1984 22(1) 47-51. 

Compounds were given orally in sesame oil at dosages from 10 to 100 mg/kg to male mice. 

Dibildox-Alvarado, E., Toro-Vasquez, J.F. 1997. Isothermal crystallization of tripalmitin in sesame oil. J. Am. Oil Chem. Soc. 74, 69-76. 

In rabbits administered several dilutions of acrolein percutaneously, the LDs°s ranged from 160-1000 mg/kg body weight, depending on the vehicle and concentration (Albin 1962). Salaman and Roe (1956) painted the backs of mice with 5 ppm acrolein (in sesame oil) for 10 weeks for a total dose of 12.6 mg and reported that acrolein did not cause mortality. 

Salaman and Roe (1956) applied acrolein (in sesame oil) to the backs of mice once a day for 10 weeks. The total dose applied was 12.6 mg (5% solution). The authors reported no tumors at the site of application or at remote sites. These results should be interpreted with caution, since the duration of the study was too short to evaluate carcinogenic potential, and only 15 mice were used. 

The critical study used by ORNL for deriving the RfD for sulfur mustard was a two-generation reproductive study (Sasser et al. 1989a) in which Sprague-Dawley rats (20 males and 27 females per group) were intragastrically intubated with sulfur mustard dissolved in sesame oil at concentrations of 0.03, 0.1, and 0.4 mg/ kg per day. Males and females were dosed for 5 days per week for 15 weeks, including 13 weeks before... 

Long-term oral carcinogenicity studies have not been conducted on sulfur mustard. In oral subchronic studies in which the agent was administered by gavage to rats (see section 3..3), epithehal hyperplasia of the forestomach occurred in 5/12 males and 5/12 females dosed with 0.3 mg HD/kg/day (in sesame oil), 5 days/week for 13 weeks. In hght of the known carcinogenicity of sulfur mustard, the epithehal hyperplasia is suggestive of a pre-neoplastic condition. 

Effects of orally administered sulfur mustard in rats were studied by Sasser et al. (1996a). Repeated gavage administration of sulfur mustard in sesame oil produced epithelial hyperplasia of the forestomach at the highest dose tested but no deaths and no other treatment-related pathological lesions or changes in clinical chemistry or hematological parameters. 

Similar to the work on sulfur mustard, Sasser et al. (1989a) conducted experiments in rats given lewisite by gastric intubation (in sesame oil) at doses of 0.01, 0.1, 0.5, 1.0, or 2.0 mg/kg, 5 days/week for 13 weeks. A dose-related response was observed for lethality (deaths in the three... 

Sesame Oil Sesame oil has traditionally been used in eastern Asian countries, especially China, Japan, Korea, and Taiwan. It has been prized for its nutritive and health-promoting values. Sesame oil, prepared from roasted sesame seeds, has a distinctive flavor and a long shelflife (86). Several studies have been reported on the flavor components of sesame oil (87-91). The amount of volatile flavor compounds in sesame oil is greatly affected by the roasting process. It has been reported that the ratio of the amount of volatile components in deep-roasted oils was increased by 2-7 times in deep-roasted oil as compared with that of light-roasted oils (90). 

TABLE 12. Changes in the Content (ppb) of Selected Odor-Active Compounds in Sesame Oils with Sesame Seeds Roasted at 160, 180, 200, and 220°C for 20 min (88, 89). 

In Mexico, safflower oil occupied a preferred status for many years in grocery stores catering to the affluent. When first produced in Mexico, a sizable portion of the safflower oil produced was used as an adulterant in sesame oil. Over time, safflower became the premier oil in the marketplace and puw cartamo would command a substantial premium. Safflower oil itself soon began to be adulterated with sunflower and other oils, and eventually consumers became aware of this and switched loyalty to branded oils that were cheaper. Little safflower oil is found in Mexico because it is generally exported to the United States or Europe, and lower priced sunflower, canola, or soybean oil is imported in its place. 

Sesame oil belongs to the oleic-linoleic acid group. It has less than 20% saturated fatty acid, mainly palmitic (7.9 12%) and stearic (4.8 6.1%) acids. Oleic acid and linoleic acid constitute more than 80% of the total fatty acids in sesame oil. Unlike other vegetable oils in this group, the percentages of oleic acid (35.9-42.3%) and linoleic acid (41.5 7.9%) in the total fatty acids of sesame oil are close (Table 5). 

Sesamin Episesamin Sesamolin Sesaminols Figure 10. Changes in sesame oil lignans induced by refining [data from Fukuda et al. (75)]. 

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