Cause Sensitization

Acute Toxicity. Plasticizers possess an extremely low order of acute toxicity LD q values are mostiy in excess of 20,000 mg/kg body weight for oral, dermal, or intraperitoneal routes of exposure. In addition to thek low acute toxicity, many years of practical use coupled with animal tests show that plasticizers do not kritate the skin or mucous membranes and do not cause sensitization. 

Health Hazards Information - Recommended Personal Protective Equipment Amine-type canister goggles or face shield rubber gloves Symptoms Following Exposure Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin General Treatment for Exposure INHALATION remove victim to fresh air INGESTION do NOT... 

Treatment with specific antibodies (ALG, ATG, anti-CD3, anti-CD25) is indicated during the induction phase after transplantation and in the case of acute rejection for short time periods. Therapy with nonhuman antibodies may cause sensitization. Muromonab-CD3 might initiate a cytokine release syndrome (fever, chills, headache). 

Some of diese preparations cause sensitivity (photophobia) to light to minimize tiiis, wear sunglasses. 

TSPP is slightly alkaline and has a bitter taste, requiring additional flavorings to mask it. Also, additional detergents must be added to keep it in solution. All of these factors can irritate oral membranes and cause sensitivity. 

RESPIRATORY SENSITIZER A substance that may cause sensitization on inhalation, causing, e.g., asthma, rhinitis or extrinsic allergic alveolitis. 

Irritating to respiratory system 43 May cause sensitization by skin... 

PHMB is very toxic to fish and aquatic life. It is moreover irritating to skin and may cause sensitization by skin contact. It can cause irritation to the eyes, nose and respiratory tract. The PHMB is not compatible with most common swimming pool chemicals. Not compatible with chlorine and chlorinated chemicals and bromine donors. Not compatible with ionic sterilizers, copper based QAC-algicides, anionic detergents, water softening chemicals, persulfate oxidants etc. The defence of the inventors of PHMB is that one should not combine it with other biocides because it should be a bactericide/algicide. But the algicidal properties of PHMB are very weak in brochures and manuals the dose is 200 ppm. 

Most chemical agents are essentially cumulative in their effects. The reason is that the human body detoxifies them very slowly or not at all. For example, a 1-h exposure to HD or CG followed within a few hours by another 1-h exposure has about the same effect as a single 2-h exposure. Continued exposure to low concentrations of HD may cause sensitivity to very low concentrations of HD. Other chemical agents also have cumulative effects. For example, an initial exposure to a small (less than lethal) amount of Sarin (GB) would decrease cholinesterase levels a second quantity less than the FDS0... 

A major class of nonaqueous solvents is the fixed oils. The USP [1] recognizes the use of fixed oils as parenteral vehicles and lists their requirements. The most commonly used oils are corn oil, cottonseed oil, peanut oil, and sesame oil. Because fixed oils can be quite irritating when injected and may cause sensitivity reactions in some patients, the oil used in the product must be stated on the label. 

Enzymatic cleaners contain enzymes derived from animals, plants, or microorganisms. Plant and micro-organism-derived enzymes may cause sensitization in many lens wearers [322], A list of commonly used enzymes is provided in Table 10. All of these enzymes are effective in removing deposits from the contact lens surface [323]. They are biochemical catalysts that are specific for catalyzing certain chemical reactions. Those... 

With the risk phrase R42 ("may cause sensitization by inhalation"),... 

The answers are 25-e, 26-b, 27-a. (Hardmanr pp 67—68. Katzung, pp 30, 134.) Anaphylaxis refers to an acute hypersensitivity reaction that appears to be mediated primarily by immunoglobulin E (IgE). Specific antigens can interact with these antibodies and cause sensitized mast cells to release vasoactive substances, such as histamine. Anaphylaxis to penicillin is one of the best-known examples the drug of choice to relieve the symptoms is epinephrine. 

Causes severe eye irritation, skin irritation, nausea, headache, and vomiting. Inhalation is irritating to the mucous membranes and upper respiratory tract. May cause sensitization by skin contact. 

Clear, colorless to pale-yellow, oily liquid with an irritating, pungent odor like mustard that is detectable at 0.008 ppm. It tends to darken on storage. This material is hazardous through inhalation, skin absorption, penetration through broken skin, and ingestion, and produces local skin/eye impacts. It causes sensitization through both inhalation and skin contact. 

Chronic Exposure Lewisite can cause sensitization and chronic lung impairment. Also, by comparison to agent mustard and arsenical compounds, it can be considered as a suspected human carcinogen. 

CHRONIC EXPOSURE to HD can cause sensitization, chronic lung impairment, (cough, shortness of breath, chest pain), and cancer of the mouth, throat, respiratory tract, skin, and leukemia. It may also cause birth defects. 

Table 7-3 (continued) Chemicals That Can Cause Sensitization... 

Symptoms of exposure Contact with skin may cause sensitization dermatitis. Ingestion may cause severe poisoning. Toxic symptoms include headache, nausea, vomiting, abdominal pain, and yellow coloration of skin (Patnaik, 1992). 

However, in some instances (due to lack of information on exposure, a small number of subjects, concomitant exposure to other substances, local or regional differences in patient referral, etc.) there may be a significant level of uncertainty associated with human data. Moreover, diagnostic tests are carried out to see if an individual is sensitized to a specific agent, and not to determine whether the agent can cause sensitization. 

Unacclimated human subjects exposed to 400 ppm for 3-5 minutes experienced nose and throat irritation. However, no adverse symptoms were observed in workmen exposed at 375-1500ppm for several months. In rare instances, exposure may cause sensitization resulting in inflammation of the mucous membranes and in eczematous eruptions. ... 

Applied locally, mercury may cause sensitization dermatitis. ... 

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